Synopsis of recent research by authors named "Marika Nestor"
- Marika Nestor's research focuses on harnessing and manipulating the p53 tumor suppressor pathway in various cancers to enhance therapeutic efficacy, particularly through the use of stapled peptides and novel immunotherapy approaches.
- Recent studies have demonstrated that MDM2/MDMX inhibitors, like Sulanemadlin, not only inhibit tumor growth but also improve the efficacy of anti-PD1 immunotherapy in wild-type p53 tumors, indicating a synergistic potential for cancer treatment.
- Nestor's work on molecular radiotherapy, particularly with [Lu]Lu-DOTATATE and specific p53-stabilizing peptides, showcases promising strategies for treating high-risk neuroblastoma and reveals how targeted therapy can be improved through radiosensitization techniques.
