Publications by authors named "Marika K Oliveira"
We report the results of a transcript finishing initiative, undertaken for the purpose of identifying and characterizing novel human transcripts, in which RT-PCR was used to bridge gaps between paired EST clusters, mapped against the genomic sequence. Each pair of EST clusters selected for experimental validation was designated a transcript finishing unit (TFU). A total of 489 TFUs were selected for validation, and an overall efficiency of 43.
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- Myosin-V plays a key role in transporting organelles and vesicles in various eukaryotic cells, from yeast to humans.
- FACS analysis revealed that peripheral blood mononuclear cells express myosin-V with similar fluorescence intensity, while confocal microscopy showed significant localization of myosin-V in the centrosomal region and throughout the cytoplasm.
- The study indicates that myosin-V is likely involved in immune response functions, as its expression increases with T-lymphocyte activation and is associated with MHC class II molecules.