Publications by authors named "Marika Groleau"
Article Synopsis
- A healthy placenta is crucial for both the mother and fetus during pregnancy, and this study uses placental weight as a measure of its growth.
- Genome-wide analyses across the genomes of mothers, fathers, and fetuses identified 40 genetic signals related to placental weight, revealing a mix of influences from both parents and the fetus.
- The findings suggest that higher placental weight, driven by fetal genetics, is linked to an increased risk of preeclampsia and shorter pregnancy duration, highlighting the role of fetal insulin in regulating placental growth.
Cullin-RING finger ligases represent the largest family of ubiquitin ligases. They are responsible for the ubiquitination of ∼20% of cellular proteins degraded through the proteasome, by catalyzing the transfer of E2-loaded ubiquitin to a substrate. Seven cullins are described in vertebrates.
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- The placenta has a unique DNA methylation profile compared to other fetal tissues, which may play specific physiological roles.
- A study analyzed the DNA methylation patterns of 444 placentas alongside cord blood samples to understand these differences.
- Findings revealed that the placenta has lower DNA methylation in certain genomic regions, linked to miRNA functions and G-protein-coupled receptor genes, highlighting its distinct regulatory mechanisms.