Publications by authors named "Marije T Nijk"
Acute myeloid leukemia (AML) often presents as an oligoclonal disease whereby multiple genetically distinct subclones can coexist within patients. Differences in signaling and drug sensitivity of such subclones complicate treatment and warrant tools to identify them and track disease progression. We previously identified >50 AML-specific plasma membrane (PM) proteins, and 7 of these (CD82, CD97, FLT3, IL1RAP, TIM3, CD25, and CD123) were implemented in routine diagnostics in patients with AML (n = 256) and myelodysplastic syndrome (n = 33).
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- * Researchers used label-free quantitative proteomics to identify 50 unique plasma membrane proteins that help isolate genetically distinct subclones from AML patients, revealing differences in drug sensitivity and growth.
- * The study demonstrates that these identified markers can be utilized for better cancer diagnosis and treatment by tracking specific leukemic clones in patients over time.
Objective: Decreased clearance of apoptotic cells is suggested to be a major pathogenic factor in systemic lupus erythematosus (SLE). The aim of this study was to investigate whether the binding of SLE autoantibodies to apoptotic cells influences the phagocytosis of these cells by macrophages.
Methods: Apoptosis was induced in a human T cell line (Jurkat) and a keratinocyte cell line (HaCaT) by ultraviolet B irradiation.