Publications by authors named "Marije J Smits"
Article Synopsis
- - Cognitive developmental delays, such as severe intellectual disability (IQ < 70) and borderline intellectual functioning (IQ 70-85), create significant challenges and costs, stressing the importance of early diagnosis and intervention.
- - High-risk groups for these delays include children with neonatal complications, congenital anomalies, and genetic disorders, but over half of cases remain unexplained, necessitating a better understanding of prognosis and functioning.
- - This review highlights the potential of using MRI to identify brain developmental markers, particularly in white matter, to improve prognostic assessments for children with cognitive developmental delay, aiming for enhanced strategies for intervention.
Background: In infants, apneas can be centrally mediated, obstructive or both and have been proposed to be gastroesophageal reflux (GER) induced. Evidence for this possible association has never been systematically reviewed.
Purpose: To perform a systematic review using PubMed, EMBASE and Cochrane databases to determine whether an association between GER and apnea in infants exists.
Objective: To systematically review the literature evaluating the diagnostic accuracy of commonly used diagnostic tests over conventional history taking and physical examination in children ≤ 18 months and >18 months suspected of gastroesophageal reflux disease (GERD).
Study Design: We searched Medline, Embase, and the Cochrane database for studies assessing the diagnostic accuracy of pH-metry, pH-impedance, esophagogastroscopy, barium contrast study, scintigraphy, and empirical treatment as diagnostic tools. Quality was assessed according to Quality Assessment of Studies of Diagnostic Accuracy Included in Systematic Reviews criteria.
Esophageal multichannel intraluminal impedance (MII) allows measurement of the conductivity of adjacent contents. During esophageal rest, raw impedance levels may represent mucosal integrity. We assessed the influence of proton pump inhibitors (PPIs) on presumed mucosal integrity by reanalyzing raw MII levels of 21 pH-MII tracings from infants with gastroesophageal reflux (GER) disease before and after esomeprazole treatment.
View Article and Find Full Text PDFIntroduction: Use of proton-pump inhibitors (PPIs) for the treatment of gastroesophageal reflux disease (GERD) in children has increased enormously. However, effectiveness and safety of PPIs for pediatric GERD are under debate.
Objectives: We performed a systematic review to determine effectiveness and safety of PPIs in children with GERD.