Prevention program for Clostridium difficile infection: a single-centre Serbian experience.

Background: Clostridium difficile (C. difficile) diarrhea is a common, iatrogenic, nosocomial disease with a worldwide diffusion. Recent studies reported that the incidence of C.

Clinical and laboratory differences between Epstein-Barr and cytomegalovirus infectious mononucleosis in children.

Introduction: Infective mononucleosis is most commonly caused by Epstein-Barr virus (EBV), and in smaller percentage by cytomegalovirus (CMV).

Objective: The aim of this paper was to determine the clinical and laboratory differences between EBV and CMV infectious mononucleosis in children.

Methods: Cohort retrospective analytical research was conducted.

Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity.

Targeting the Mdm2 oncoprotein by drugs has the potential of re-establishing p53 function and tumor suppression. However, Mdm2-antagonizing drug candidates, e. g.

CYP1A2 genotype affects carbamazepine pharmacokinetics in children with epilepsy.

Purpose: The purpose of this study is to investigate the effect of two of the most important functional CYP1A2 variations -3860G > A and -163C > A on carbamazepine pharmacokinetics in Serbian pediatric epileptic patients.

Methods: The study involved 40 Serbian pediatric epileptic patients on steady-state carbamazepine treatment. Genotyping for -3860G > A and -163C > A was carried out using PCR-RFLP method, and carbamazepine plasma concentrations were determined by high pressure liquid chromatography (HPLC) method.

[Brain abscesses in neonates: neurosonographic diagnosis and long-term follow-up].

Brain abscesses were neurosongraphically diagnosed in 3 out of 44 neonates who had confirmed purulent meningitis. In two cases, the cause was Proteus mirabillis, whereas in one the cause could not be isolated. The ultrasound finding indicated abscess cavities localised in the frontal (in one case bilaterally) and temporal regions of the CNS.