Publications by authors named "Marija Kacar"
Article Synopsis
- - Childhood melanoma is a rare type of skin cancer in kids that can vary greatly in its biological characteristics.
- - Diagnosing pediatric melanoma can be complicated because it shares similarities with various other tumors.
- - A new fusion gene called MED15::ATF1 has been found in a specific case of aggressive pediatric melanoma that shows spitzoid features.
Article Synopsis
- The study looked at using higher doses of radiation therapy (RT) for kids and young adults with big tumors from Ewing sarcoma (EWS) to see if it helps control the cancer better.
- They treated patients with tumors 8 cm or larger using special types of radiation and found that most of them had good results over 5 years, with a 64.2% chance of surviving.
- Although many patients had side effects from the treatment, most were not very serious, showing that the higher doses of radiation might be safe and effective.
Progressive metastatic infantile fibrosarcoma with multiple acquired mutations.
Cold Spring Harb Mol Case Stud
April 2023
Infantile fibrosarcoma is the most common soft-tissue sarcoma in children under the age of 1 yr and is defined molecularly by fusion proteins. This tumor is known to be locally invasive; however, although rare, metastases can occur. The fusion acts as a driver for tumor formation, which can be targeted by first- and second-generation inhibitors.
View Article and Find Full Text PDFBackground: Chemotherapy-induced nausea and vomiting (CINV) is a distressing adverse effect in children receiving cancer treatment. There are evidence-based pediatric clinical practice guidelines (CPG) on chemotherapy emetogenicity and acute CINV prevention, but adherence to these guidelines is low.
Procedure: A quality improvement-based study was conducted at McMaster Children's Hospital.
A 4-year-old male with painless hematuria, anemia, and jaundice.
Paediatr Child Health
December 2022
Background: Frosted branch angiitis (FBA) is a rare phenomenon of panuveitis which may occur secondary to cytomegalovirus (CMV) causing acute visual disturbances. CMV infection is a known complication in allogenic stem cell transplant (SCT) patients but is uncommon following autologous SCT.
Observation: We describe a 17-month-old medulloblastoma patient with sudden onset visual impairment following second autologous SCT.
A Case of a Pediatric Patient With Protein S Heerlen Polymorphism and Deep Venous Thrombosis.
J Pediatr Hematol Oncol
March 2022
Hereditary protein S (PS) deficiency is a rare autosomal dominant disorder with increased risk of venous thromboembolism. The PS Heerlen polymorphism at codon 501 of the PROS1 gene is considered a variant of uncertain significance. It has since been shown that PS Heerlen has a reduced half-life, resulting in reduced levels of free PS.
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