Predictors of Mortality in Early Neonatal Sepsis: A Single-Center Experience.

: Early neonatal sepsis is associated with a significant mortality rate despite modern treatment strategies. Our aim was to identify risk factors contributing to the occurrence of death in newborns with early neonatal sepsis. : We conducted a retrospective cross-sectional study that included newborns with early sepsis who received care in the intensive and semi-intensive care units at the Institute of Neonatology, Belgrade, Serbia.

Divergent effect of fast- and slow-releasing HS donors on boar spermatozoa under oxidative stress.

Hydrogen sulphide (HS) is involved in the physiology and pathophysiology of different cell types, but little is known about its role in sperm cells. Because of its reducing properties, we hypothesise that HS protects spermatozoa against the deleterious effects of oxidative stress, a condition that is common to several male fertility disorders. This study aimed i) to determine the total antioxidant capacities of NaS and GYY4137, which are fast- and slow-releasing HS donors, respectively, and ii) to test whether HS donors are able to protect spermatozoa against oxidative stress.

Aminoguanidine Protects Boar Spermatozoa against the Deleterious Effects of Oxidative Stress.

Aminoguanidine is a selective inhibitor of the inducible nitric oxide synthase (iNOS) and a scavenger of reactive oxygen species (ROS). Numerous studies have shown the antioxidant properties of aminoguanidine in several cell lines, but the in vitro effects of this compound on spermatozoa under oxidative stress are unknown. In this study, we tested the hypothesis that aminoguanidine may protect against the detrimental effects of oxidative stress in boar spermatozoa.