Publications by authors named "Mariia Bogdanova"
Pediatric-onset multiple sclerosis (POMS), is the manifestation of multiple sclerosis in individuals before 18 years of age. About a third of children with POMS show some form of lower cognitive performance. The purpose of this study is to examine using quantitative meta-analyses the effect size of altered performance between children with and without POMS on overall intelligence quotient (IQ), information processing speed, and language functions.
View Article and Find Full Text PDFBackground: Identification of novel biomarkers could provide prognostic information and improve risk stratification in patients with aortic stenosis (AS). YKL-40 (chitinase-3-like protein 1), a protein involved in atherogenesis, is upregulated in human calcific aortic valves. We hypothesized that circulating YKL-40 would be elevated and associated with the degree of AS severity and outcome in patients with symptomatic AS.
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- The study examines how the patterns of 5-hydroxymethylcytosine (5hmC) change in human preimplantation embryos during the process of DNA methylation reprogramming.
- It reveals that in zygotes, 5hmC is more concentrated in the paternal chromosome set and is specifically localized to certain regions, known as R-bands, while being sparse in the maternal set.
- As embryonic cleavage occurs, there is a loss of 5hmC and its distribution becomes less symmetrical among sister chromatids, indicating dynamic changes in hydroxymethylation patterns throughout early development.