Publications by authors named "Marife Medina"
Article Synopsis
- A new study indicates that there's no simple method for detecting HAART-associated lipodystrophy in HIV patients, highlighting the need for better diagnostic approaches.
- Researchers analyzed the relationship between a subjective grading scale for lipodystrophy and measurements of fat thickness in 74 HIV-infected patients, finding strong correlations, particularly in limb circumferences and perirenal fat.
- The study suggests categorizing lipodystrophy as absent, mild, or marked based on these measurements, emphasizing that even slight changes in appearance should be taken seriously for early detection in clinical settings.
Echographically measured thicknesses of perirenal and subcutaneous fat, as well as serum metabolic and anthropometric parameters, were evaluated in 74 human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy (HAART), 22 of whom were HAART-naive at baseline, who were followed-up for 27 months to detect predictive factors of lipodystrophy. Perirenal fat diameter (PRFD) at baseline differed in HAART-naive and HAART-experienced patients (P<.001), and it was the best predictor of lipodystrophy changes after 12 months of follow-up in the HAART-naive patients (hazard ratio, 7.
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