Publications by authors named "Marietta K Saldias Montivero"
Over the past century, human lifespan has increased remarkably, yet the inevitability of aging persists. The disparity between biological age, which reflects pathological deterioration and disease, and chronological age, indicative of normal aging, has driven prior research focused on identifying mechanisms that could inform interventions to reverse excessive age-related deterioration and reduce morbidity and mortality. DNA methylation has emerged as an important predictor of age, leading to the development of epigenetic clocks that quantify the extent of pathological deterioration beyond what is typically expected for a given age.
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- Spatial transcriptomics technologies are revolutionizing research by enabling the study of cellular and molecular dynamics within tissues, enhancing our understanding of development, disease, and tumor environments.
- Photoaging, caused by sun exposure, affects skin health and is linked to skin cancer, and spatial transcriptomics can provide a reliable method for evaluating its impact and developing new treatments.
- Despite challenges like high costs and patient variability in current technologies, using routine H&E-stained slides in combination with spatial transcriptomics can help analyze gene expression in skin specimens, potentially revealing valuable insights into photoaging and therapeutic efficacy.