Publications by authors named "Marielle Sophie Ernst"
Background: Benefits and challenges resulting from advances in genetic diagnostics are two sides of the same coin. Facilitation of a correct and timely diagnosis is paralleled by challenges in interpretation of variants of unknown significance (VUS). Focusing on an individual VUS-re-classification pipeline, this study offers a diagnostic approach for clinically suspected hereditary muscular dystrophy by combining the expertise of an interdisciplinary team.
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- The study looked at whether doing a procedure called thrombectomy by itself is just as good as doing thrombectomy with a medicine called alteplase for patients who have a stroke caused by a blocked blood vessel.
- Researchers in Europe and Canada tested this by randomly assigning stroke patients to either just thrombectomy or thrombectomy plus alteplase.
- They wanted to see if the patients who only had thrombectomy would have similar recovery outcomes to those who had both treatments, and they kept track of how well everyone was doing over 90 days.
Background: Decision-making about the indication for decompressive hemicraniectomy in cases with malignant infarction in the territory of the middle cerebral artery (MCA) is still a matter of debate. Some scores have been introduced and tested, most of them are midline-shift dependent. We introduce the Kinematics of malignant MCA infarction (KM) index, which can be calculated based on an initial computed tomography perfusion scan and the chosen therapy (lysis/thrombectomy/conservative) in order to estimate the maximum midline-shift in the subsequent 6 days.
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