Propranolol failed to prevent severe stress-induced long-term behavioral changes in male rats.

Memories of adverse events can be maladaptive when they lead to exaggerated fear, as observed in post-traumatic stress disorder (PTSD). Fear conditioning and fear sensitization are learning processes thought to play a role in fear-related disorders, and only few animal studies have evaluated the relationship between the associative and non-associative fear memory components on the development and maintenance of PTSD-like behavioral changes. Here we assessed the effects of a single dose of propranolol (10 mg/kg) or saline after fear memory retrieval on the long-term behavioral responses induced by severe stress in male rats.

Variability in response to severe stress: highly reactive rats exhibit changes in fear and anxiety-like behavior related to distinct neuronal co-activation patterns.

There is an important individual variability in development of posttraumatic stress disorder (PTSD) and this feature needs to be better addressed in preclinical studies. Previously we showed that only rats that explored the context before a foot shock (delayed shock group) exhibited long-lasting behavioral changes. In this study the delayed shock group was segregated using the freezing response upon re-exposure to the shock-paired context and we investigated whether higher reactivity would be related to behavioral alterations and to activation of brain regions using Fos immunoreactivity.

Understanding posttraumatic stress disorder through fear conditioning, extinction and reconsolidation.

Careaga MBL, Girardi CEN, Suchecki D. Understanding posttraumatic stress disorder through fear conditioning, extinction and reconsolidation. NEUROSCI BIOBEHAV REV -Posttraumatic stress disorder (PTSD) is a psychopathology characterized by exacerbation of fear response.

Corrigendum: Pre-test metyrapone impairs memory recall in fear conditioning tasks: lack of interaction with β-adrenergic activity.

[This corrects the article on p. 51 in vol. 9, PMID: 25784866.

Pre-test metyrapone impairs memory recall in fear conditioning tasks: lack of interaction with β-adrenergic activity.

Cognitive processes, such as learning and memory, are essential for our adaptation to environmental changes and consequently for survival. Numerous studies indicate that hormones secreted during stressful situations, such as glucocorticoids (GCs), adrenaline and noradrenaline, regulate memory functions, modulating aversive memory consolidation and retrieval, in an interactive and complementary way. Thus, the facilitatory effects of GCs on memory consolidation as well as their suppressive effects on retrieval are substantially explained by this interaction.