Exploring New Multimodal Quantitative Imaging Indices for the Assessment of Osseous Tumor Burden in Prostate Cancer Using Ga-PSMA PET/CT.

PET combined with CT and prostate-specific membrane antigen (PSMA) ligands has gained significant interest for staging prostate cancer (PC). In this study, we propose 2 multimodal quantitative indices as imaging biomarkers for the assessment of osseous tumor burden using Ga-PSMA PET/CT and present preliminary clinical data. We defined 2 bone PET indices (BPIs) that incorporate anatomic information from CT and functional information from Ga-PSMA PET: BPI is the percentage of bone volume affected by tumor and BPI additionally considers the level of PSMA expression.

Comparison of bone scintigraphy and Ga-PSMA PET for skeletal staging in prostate cancer.

Purpose: The aim of our study was to compare the diagnostic performance of Ga-PSMA PET and Tc bone scintigraphy (BS) for the detection of bone metastases in prostate cancer (PC) patients.

Methods: One hundred twenty-six patients who received planar BS and PSMA PET within three months and without change of therapy were extracted from our database. Bone lesions were categorized into benign, metastatic, or equivocal by two experienced observers.