Publications by authors named "Mariela Uyaguari"
Objectives: Giant cell arteritis (GCA) is a large/medium-vessel granulomatous vasculitis, and the PD-1/PD-L1 coinhibitory pathway seems to be implicated in its pathogenesis. CD4 T cells expressing high PD-1 levels, CD4+CXCR5-PD-1hi peripheral helper (Tph) and CD4+CXCR5+PD-1hi follicular helper T cells (Tfh), are key mediators of autoimmunity. Their frequencies are elevated in the peripheral blood of subjects with several autoimmune conditions but have not been investigated in GCA.
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- This study examines the role of circulating follicular helper T (cTfh) cells in Rheumatoid Arthritis (RA) and how treatment with abatacept (ABT) or TNF blockers (TNFb) affects their frequency.
- Researchers analyzed blood samples from RA patients on different treatments, revealing that cTfh frequency is higher in RA patients but notably decreases with ABT treatment, while it stays the same with TNFb.
- Findings suggest that a higher cTfh frequency at baseline indicates a positive response to ABT but a negative response to TNFb, highlighting distinct impacts of these treatments on immune cell dynamics in RA.