Long-term Outcomes of Infliximab Use for Pediatric Crohn Disease: A Canadian Multicenter Clinical Practice Experience.

Background: Data on long-term real-world outcomes of infliximab in pediatric Crohn disease are limited.

Aim: The aim of the study was to evaluate infliximab optimization and durability in children with Crohn disease.

Methods: We performed a retrospective review of children with Crohn disease who started infliximab from January 2008 to December 2012 in 4 Canadian tertiary care centers.

CYP17A1 and Blood Pressure Reactivity to Stress in Adolescence.

Adolescents who exhibit exaggerated blood pressure (BP) reactivity to physical and mental challenges are at increased risk of developing hypertension in adulthood. BP at rest and in response to challenges is higher in males than females, beginning in early adolescence. CYP17A1 is one of the well-established gene loci of adult hypertension.