Publications by authors named "Mariel Valdivia Mazeyra"
Secondary hyperoxaluria is a metabolic disorder characterized by an increase in urinary oxalate excretion. The etiology may arise from an increase in the intake of oxalate or its precursors, decreased elimination at the digestive level, or heightened renal excretion. Recently, the role of the SLC26A6 transporter in the etiopathogenesis of this disease has been identified.
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- Primary Sjögren's syndrome (pSS) is an autoimmune disorder influenced by type I and II interferons, with an inadequate focus on the role of innate immune cells like NK and dendritic cells.
- Researchers found a specific NK cell subset in pSS patients that is more effective at killing cells and detected higher levels of a certain type of dendritic cell (cDC2) involved in inflammation.
- The study suggests that the interaction between these NK cells and cDC2s, along with specific signaling pathways, plays a key role in pSS development, highlighting potential new targets for therapy.
From 2000, Mesoamerican region has reached an important rate of chronic kidney disease of unknown etiology. Under the name of Meroamerican Nephropathy (MeN) several hypotheses (including dehydration, heat stress, environmental or toxic exposure or even infections) have tried to explain the etiology this new disease. MeN affects young men, agricultural workers exposed to high temperatures.
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- There is a potential link between systemic sarcoidosis (SS) and cancer, where SS may be triggered by factors related to tumors and cancer treatments.
- A study reviewed 196 patients with sarcoidosis, finding that 47 had a history of tumors, and in 29 cases examined, 12 displayed tumor-associated granulomas (TAGs).
- The prevalence of TAGs in these patients (41.4%) was much higher compared to the normal population, suggesting a significant relationship between sarcoidosis and previous neoplasia.
From 2000, Mesoamerican region has reached an important rate of chronic kidney disease of unknown etiology. Under the name of Meroamerican Nephropathy (MeN) several hypotheses (including dehydration, heat stress, environmental or toxic exposure or even infections) have tried to explain the etiology this new disease. MeN affects young men, agricultural workers exposed to high temperatures.
View Article and Find Full Text PDFIntroduction: Multinucleated giant cells (MGC) are a rare finding when evaluating axillary sentinel lymph nodes. Some are described as foreign body-type MGC accompanied by foamy macrophages. They have been rarely reported in nodes from patients in which a previous breast biopsy was performed.
View Article and Find Full Text PDFPulmonary megakaryocytes participate in the pathogenesis of lung damage, particularly in acute lung injury. Although megakaryocytes are not mentioned as a characteristic histologic finding associated to pulmonary injury, a few studies reveal that their number is increased in diffuse alveolar damage (DAD). In this autopsy study, we have observed a relevant number of pulmonary megakaryocytes in COVID-19 patients dying with acute lung injury (7.
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