Children's Physical Proximity to Interparental Conflict: Resilient Process and Retrospective Perceptions of Parent-Child Relationships.

This retrospective study sought to determine (a) whether physical proximity to interparental conflict in childhood moderates the link between frequency of exposure to interparental conflict and subsequent levels of resilience in adulthood and (b) whether retrospective perceptions of parent-child relations and insecurity mediate the link between interparental conflict and resilient development. A total of 963 French students aged 18-25 years were assessed. Our study showed that the children's physical proximity to interparental conflict is a major long-term risk factor for their subsequent development and their retrospective perceptions of parent-child relations.

First evidence of protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptides.

Post-stroke depression (PSD) is the most common mood disorder following stroke with high relevance for outcome and survival of patients. The TREK-1 channel represents a crucial target in the pathogenesis of stroke and depression. Spadin and its short analog mini-spadin were reported to display potent antidepressant properties.

Fighting against depression with TREK-1 blockers: Past and future. A focus on spadin.

Depression is a devastating mood disorder and a leading cause of disability worldwide. Depression affects approximately one in five individuals in the world and represents heavy economic and social burdens. The neurobiological mechanisms of depression are not fully understood, but evidence highlights the role of monoamine neurotransmitter balance.

Altered Trek-1 Function in Sortilin Deficient Mice Results in Decreased Depressive-Like Behavior.

The background potassium channel TREK-1 has been shown to be a potent target for depression treatment. Indeed, deletion of this channel in mice resulted in a depression resistant phenotype. The association of TREK-1 with the sorting protein sortilin prompted us to investigate the behavior of mice deleted from the gene encoding sortilin ().

Shortened Spadin Analogs Display Better TREK-1 Inhibition, Stability and Antidepressant Activity.

Depression is a devastating mental disorder that affects 20% of the population worldwide. Despite their proven efficacy, antidepressants present a delayed onset of action and serious adverse effects. Seven years ago, we described spadin (PE 12-28) as a promising endogenous peptide with antidepressant activity.

Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications.

During cortical development, the identity of major classes of long-distance projection neurons is established by the expression of molecular determinants, which become gradually restricted and mutually exclusive. However, the mechanisms by which projection neurons acquire their final properties during postnatal stages are still poorly understood. In this study, we show that the number of neurons co-expressing Ctip2 and Satb2, respectively involved in the early specification of subcerebral and callosal projection neurons, progressively increases after birth in the somatosensory cortex.

Neurogenesis-independent antidepressant-like effects of enriched environment is dependent on adiponectin.

Environmental enrichment (EE) that combines voluntary physical exercise, sensory and social stimuli, causes profound changes in rodent brain at molecular, anatomical and behavioral levels. Here, we show that EE efficiently reduces anxiety and depression-like behaviors in a mouse model of depression induced by long-term administration of corticosterone. Mechanisms underlying EE-related beneficial effects remain largely unexplored; however, our results point toward adiponectin, an adipocyte-secreted protein, as a main contributor.

Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development.

Enriched environment (EE) is characterized by improved conditions for enhanced exploration, cognitive activity, social interaction and physical exercise. It has been shown that EE positively regulates the remodeling of neural circuits, memory consolidation, long-term changes in synaptic strength and neurogenesis. However, the fine mechanisms by which environment shapes the brain at different postnatal developmental stages and the duration required to induce such changes are still a matter of debate.