Publications by authors named "Marieke v d Hart"
J Neurosci Methods
April 2009
Article Synopsis
- Microdialysis is the primary method for measuring drug levels in the brain of living animals, but traditional quantitative techniques face significant challenges in accuracy and require many animals.
- The dynamic no-net-flux (DNNF) method has been seen as a solution but demands high precision and can produce complex data.
- A modified ultraslow microdialysis approach enhances recovery rates and simplifies the process, showing promise in measuring CNS compound levels effectively with fewer animals, making it easier to study drug penetration through the blood-brain barrier.
