Publications by authors named "Marieke Schouw"
Article Synopsis
- Antipsychotic-induced Weight Gain (AiWG) is a significant side effect of antipsychotic medications that can lead to serious health issues, including diabetes and decreased quality of life, but optimal treatment strategies are still unclear.
- This study is a randomized, double-blind trial that will compare the effects of metformin against a placebo in 256 overweight patients (BMI > 25) with schizophrenia who have been on antipsychotics for at least three months.
- The primary goal is to assess changes in body weight after 26 weeks of treatment, with secondary outcomes including the impact on metabolic syndrome, quality of life, and overall health, as well as evaluating cost-effectiveness and genetic factors related to BMI.
Background: Animal studies have shown that methylphenidate (MPH) and fluoxetine (FLX) have different effects on dopaminergic and serotonergic system in the developing brain compared to the developed brain. The effects of Psychotropic drugs On the Developing brain (ePOD) study is a combination of different approaches to determine whether there are related findings in humans.
Methods/design: Animal studies were carried out to investigate age-related effects of psychotropic drugs and to validate new neuroimaging techniques.
Preliminary evidence of hippocampal damage in chronic users of ecstasy.
J Neurol Neurosurg Psychiatry
January 2012
Various studies have shown that ecstasy (3,4-methylenedioxymethamphetamine) users display significant memory impairments, whereas their performance on other cognitive tests is generally normal. The hippocampus plays an essential role in short-term memory. There are, however, no structural human data on the effects of ecstasy on the hippocampus.
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