Publications by authors named "Marieke R Wensveen"
Article Synopsis
- DNA double-strand breaks (DSBs) are critical to repair for maintaining genome stability, with different chromatin types potentially requiring distinct repair mechanisms.
- In a study involving Drosophila melanogaster, it was found that DSBs in facultative heterochromatin quickly move outside of specialized structures called polycomb bodies and this movement corresponds with a decrease in a specific histone mark, H3K27me3.
- The research indicates that the histone demethylase dUtx is essential for this process, as its absence disrupts both the movement of DSBs and the completion of repair via homologous recombination in heterochromatic regions.
The eukaryotic nucleus is continuously being exposed to endogenous and exogenous sources that cause DNA breaks, whose faithful repair requires the activity of dedicated nuclear machineries. DNA is packaged into a variety of chromatin domains, each characterized by specific molecular properties that regulate gene expression and help maintain nuclear structure. These different chromatin environments each demand a tailored response to DNA damage.
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