Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis.

 To provide evidence to support updated guidelines for the management of pregnant women with hereditary thrombophilia in order to reduce the risk of a first venous thromboembolism (VTE) in pregnancy. Systematic review and bayesian meta-analysis. Embase, Medline, Web of Science, Cochrane Library, and Google Scholar from inception through 14 November 2016.

Advances in the detection of pulmonary embolism.

Background: Diagnosing or excluding pulmonary embolism is a complex challenge. Many diagnostic instruments can be used in patients with clinically suspected pulmonary embolism nowadays, all with their own (dis-)advantages. Methods/objectives: In this review, these (dis-)advantages are discussed for the following diagnostic instruments: clinical probability assessment, D-dimer concentration, the combination of clinical probability assessment and D-dimer concentration, bilateral compression ultrasonography, ventilation/perfusion scintigraphy, computerized tomographic pulmonary angiography, pulmonary angiography and magnetic resonance pulmonary angiography.