Publications by authors named "Marieke F J Buijtendijk"
Article Synopsis
- * Large-scale initiatives have emerged over the last decade, relying on biobanks for high-quality images and tissue samples to further investigate human development.
- * The paper discusses the establishment of the Dutch Fetal Biobank, covering its framework, legal and ethical considerations, and initial findings from 329 tissue specimens.
Due to advancements in ultrasound techniques, the focus of antenatal ultrasound screening is moving towards the first trimester of pregnancy. The early first trimester however remains in part, a 'black box', due to the size of the developing embryo and the limitations of contemporary scanning techniques. Therefore there is a need for images of early anatomical developmental to improve our understanding of this area.
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- Tricuspid valve agenesis/atresia (TVA) is a birth defect where the tricuspid valve doesn't form, potentially due to improper development of the atrioventricular canal (AVC).
- Researchers used high-resolution imaging to study fetal hearts with TVA and tricuspid valve stenosis (TVS), finding a deeper right atrioventricular sulcus in TVA cases, supporting the hypothesis of AVC expansion failure.
- In a study of 23 TVA and 16 TVS fetuses, results showed that while overall heart dimensions increased with age, TVA presented a significantly lower AVC to ventricular width ratio in the second trimester, although this normalized by the third trimester due to possible compensatory growth.
In 2014, an extensive review discussing the major steps of cardiac development focusing on growth, formation of primary and chamber myocardium and the development of the cardiac electrical system, was published. Molecular genetic lineage analyses have since furthered our insight in the developmental origin of the various component parts of the heart, which currently can be unambiguously identified by their unique molecular phenotype. Moreover, genetic, molecular and cell biological analyses have driven insights into the mechanisms underlying the development of the different cardiac components.
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