Publications by authors named "Marie-Rose Mellander"
Article Synopsis
- Microscopic colitis (MC) includes two subtypes: collagenous colitis (CC) and lymphocytic colitis (LC), and their relationship as either distinct entities or a continuum needs further investigation.
- A genome-wide association study (GWAS) involving nearly 15,000 individuals found a strong link between HLA alleles and collagenous colitis, highlighting specific alleles and their variants as significant factors.
- The findings suggest that CC and LC have different biological mechanisms, particularly with HLA's relevant role in CC, which raises questions about current definitions and classifications of microscopic colitis.
Article Synopsis
- The study aimed to investigate the connections between microscopic colitis (MC) and various genes related to tight junction (TJ) proteins, given that MC is linked to increased intestinal permeability.* -
- In a case-control study involving over 500 participants, significant associations were found between specific single nucleotide polymorphisms (SNPs) in the PTEN, MAGI1, and F11R genes and the risk of developing MC, especially collagenous colitis (CC).* -
- Results suggest that lower expression levels of PTEN and MAGI1 in the colon may play a role in the development of MC and its subtypes, highlighting these genes as potential genetic risk factors.*
Objective: Microscopic colitis is a common cause of chronic diarrhoea in the Scandinavian countries. This report comprises demographic data, clinical and endoscopic features, and occurrence of coeliac and inflammatory bowel disease (IBD) in a large urban cohort of patients with lymphocytic colitis (LC) and collagenous colitis (CC).
Materials And Methods: A total of 795 patients with microscopic colitis from two hospitals in Stockholm were included.
Objective: Collagenous colitis (CC) is a major cause of chronic non-bloody diarrhoea, particularly in the elderly female population. The aetiology of CC is unknown, and still poor is the understanding of its pathogenesis. This possibly involves dysregulated inflammation and immune-mediated reactions in genetically predisposed individuals, but the contribution of genetic factors to CC is underinvestigated.
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