Publications by authors named "Marie-Quitterie Picat"
Purpose: Anti-angiogenic and mammalian target of rapamycin inhibitors have shown efficacy in solid tumours. Reported combination of both drugs was deemed to be too toxic. Due to a potential favourable safety profile of axitinib (AX), a phase I study combining everolimus (EV) and AX for solid tumours was explored.
View Article and Find Full Text PDFA multicenter phase II study of sunitinib in patients with locally advanced or metastatic differentiated, anaplastic or medullary thyroid carcinomas: mature data from the THYSU study.
Eur J Cancer
May 2017
Article Synopsis
- The study aimed to evaluate the effectiveness of sunitinib, a vascular endothelial growth factor receptor inhibitor, for treating patients with advanced radioactive iodine-resistant differentiated thyroid cancer (MDTC) and medullary thyroid cancer (MMTC).
- In a phase 2 trial involving 71 patients, the objective response rates were 22% for MDTC patients and 38.5% for MMTC patients, with median progression-free survival of 13.1 months for MDTC and 16.5 months for MMTC. The study highlighted the need for careful monitoring due to significant side effects, including severe fatigue and a notable percentage of cardiac events.
- The authors concluded that while sunitin
Objectives: To unravel the complex relationships between cytomegalovirus-induced-, autoimmune-induced responses, microbial translocation and chronic immune activation (CIA) in successfully treated HIV-infected patients and to explore the mediating role of alpha-interferon in these processes.
Design: Cross-sectional study nested in the ANRS CO3 Aquitaine Cohort, a prospective hospital-based cohort of HIV-1-infected patients in South-Western France.
Methods: Patients initiated antiretroviral therapy between 2005 and 2008 and were treated with sustained virological suppression for at least two years.
Tinea capitis (TC) is a highly contagious fungal infection of the scalp due to dermatophytes in children. To obtain information on the epidemiology of TC in the urban area of Paris, we analysed the microbiological results of 3090 patients seen with suspected TC from October 2010 to September 2015 at Saint Louis hospital, Paris, France. A peak of TC was observed in 3-6 year-old children, followed by a progressive decrease until 16 years of age.
View Article and Find Full Text PDFObjective: To assess the effect of pelvic drainage after rectal surgery for cancer.
Background: Pelvic sepsis is one of the major complications after rectal excision for rectal cancer. Although many studies have confirmed infectiveness of drainage after colectomy, there is still a controversy after rectal surgery.
Background: Specific noninvasive signal processing was applied to identify drivers in distinct categories of persistent atrial fibrillation (AF).
Methods And Results: In 103 consecutive patients with persistent AF, accurate biatrial geometry relative to an array of 252 body surface electrodes was obtained from a noncontrast computed tomography scan. The reconstructed unipolar AF electrograms acquired at bedside from multiple windows (duration, 9±1 s) were signal processed to identify the drivers (focal or reentrant activity) and their cumulative density map.
Article Synopsis
- Symptomatic Primary Humoral Immunodeficiency Diseases (PHID) are characterized by low antibody levels, resulting in a higher risk of infections, and are associated with various immunological abnormalities.
- Researchers analyzed 81 symptomatic PHID patients and identified five distinct groups, revealing that certain immune cell changes, specifically in B-cells and activated T-cells, were linked to complications in these patients.
- The study suggests that including T-cell activation markers could enhance the classification and prognosis of PHID, helping identify patients at risk for more severe complications.
Background: Long-term immune reconstitution on antiretroviral therapy (ART) has important implications for HIV-infected children, who increasingly survive into adulthood. Children's response to ART differs from adults', and better descriptive and predictive models of reconstitution are needed to guide policy and direct research. We present statistical models characterising, qualitatively and quantitatively, patterns of long-term CD4 recovery.
View Article and Find Full Text PDFCurrently in oncology a novel agent entering development has only 5% chance of making it to commercial use. One of the ways to mitigate this problem would be to conduct exploratory or 'phase 0' clinical trials, conducted before phase 1 dose-escalation safety and tolerance studies. These phase 0 studies are a first administration of the novel agent to humans, at limited doses, on a small number of patients and over a short period.
View Article and Find Full Text PDFBackground: Autoimmune hemolytic anemia is a rare condition in children. Little is known about its initial presentation and the subsequent progression of the disease.
Design And Methods: Since 2004, a national observational study has been aiming to thoroughly describe cases and identify prognostic factors.