Publications by authors named "Marie-Pier Forest"
Article Synopsis
- - SHP-1 is a protein that helps regulate glucose and lipid balance and its role in regulating PPARγ2, a key player in fat cell development (adipogenesis), was previously unexplored.
- - The study found that SHP-1 interacts with PPARγ2 via its SH2 domain and can reduce the tyrosine phosphorylation on PPARγ2, leading to decreased stability of this protein.
- - When SHP-1 is lost, PPARγ2's activation increases, resulting in higher expression of its target genes and more lipid accumulation in cells, but blocking PPARγ2's phosphorylation can lessen this effect.
Unlabelled: Hepatocyte-specific Shp1 knockout mice (Ptpn6(H-KO)) are protected from hepatic insulin resistance evoked by high-fat diet (HFD) feeding for 8 weeks. Unexpectedly, we report herein that Ptpn6(H-KO) mice fed an HFD for up to 16 weeks are still protected from insulin resistance, but are more prone to hepatic steatosis, as compared with their HFD-fed Ptpn6(f/f) counterparts. The livers from HFD-fed Ptpn6(H-KO) mice displayed 1) augmented lipogenesis, marked by increased expression of several hepatic genes involved in fatty acid biosynthesis, 2) elevated postprandial fatty acid uptake, and 3) significantly reduced lipid export with enhanced degradation of apolipoprotein B (ApoB).
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