Publications by authors named "Marie-Odile Marcoux"
The aim is to conduct a pilot study to prospectively describe echocardiographic parameters in neonates with pulmonary hypertension (PH) managed according to current recommendations and to identify those parameters that could predict worsening of short-term outcomes. All neonates less than 28 days old with a diagnosis of PH were prospectively enrolled in a tertiary care center for 1 year. Two echocardiograms were performed by a trained neonatologist.
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- The study aimed to compare the effectiveness of two different flow rates (2 L/kg/min and 3 L/kg/min) for high-flow nasal cannula therapy in infants with acute viral bronchiolitis.
- Results showed similar failure rates in both groups, with respiratory distress being the main reason for failure; however, discomfort and length of stay in the pediatric ICU were greater in the 3 L/kg/min group.
- The conclusion indicated that increasing the flow rate to 3 L/kg/min did not provide any additional benefits over 2 L/kg/min for managing respiratory support in these infants.
Importance: Propofol or a combination of a synthetic opioid and muscle relaxant are both recommended for premedication before neonatal intubation but have yet to be compared.
Objective: To compare prolonged desaturation during neonatal nasotracheal intubation after premedication with atropine-propofol vs atropine-atracurium-sufentanil treatment.
Design, Setting, And Participants: Multicenter, double-blind, randomized clinical trial (2012-2016) in 6 NICUs in France that included 173 neonates requiring nonemergency intubation.
Objective: To evaluate the status of congenital diaphragmatic hernia (CDH) management in France and to assess predictors of adverse outcomes.
Study Design: We reviewed the first-year outcome of all cases of CDH reported to the French National Register in 2011.
Results: A total of 158 cases were included.
Aim: Water channel AQP2 is the target for vasopressin (AVP) and a major determinant of urinary concentrating capacity. In mature kidneys, prostaglandins counteract the effect of AVP on AQP2 expression at functional sites. We investigated whether disturbances in water homeostasis in infants with patent ductus arteriosus (PDA) treated with prostaglandin inhibitors can be attributed to activation of AQP2.
View Article and Find Full Text PDFAim: The aim of the study was to determine whether neonatal respiratory distress is related to changes in water and ion transporter expression in lung epithelium.
Methods: The study included 32 neonates on mechanical ventilation: 6 patients with normal lung X-rays (control group), eight with respiratory distress syndrome (RDS), eight with transient tachypnea of the newborn (TTN), 10 with abnormal lung X-rays (mixed group). The protein abundance of water channel AQP5, epithelial sodium channel (ENaC; alpha-, beta- and gamma-ENaC) and Na(+), K(+)-ATPase alpha1 were examined in tracheal aspirates using semiquantitative immunoblotting.