Publications by authors named "Marie-Odile Jauberteau-Marchan"
Article Synopsis
- Tumors in the peritoneal serosa, known as peritoneal carcinosis, can arise from primary conditions or the spread of cancers from other organs, primarily affecting the digestive and gynecological systems.
- The treatment focuses on maximizing tumor removal (cytoreduction) along with hyperthermic intra-abdominal chemotherapy to target remaining microscopic cancer cells.
- Recent advancements in delivery methods for chemotherapy aim to enhance survival rates for patients with these malignant conditions, but further randomized controlled trials are necessary to confirm treatment effectiveness, utilizing insights from molecular biology and genetics.
BDNF and pro-BDNF in serum and exosomes in major depression: Evolution after antidepressant treatment.
Prog Neuropsychopharmacol Biol Psychiatry
July 2021
Background: The study of clinically related biological indicators in Major Depression (MD) is important. The Brain Derived Neurotrophic Factor (BDNF) appears to play an important role in MD, through its neurotrophic effect, and its levels are significantly decreased. The variation in the serum levels of its precursor proBDNF, which has opposite effects, is not known.
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- The study highlights the limited research on visible light effects compared to ultraviolet light, revealing that blue light can inhibit melanoma cell growth and reduce cell cycle progression.
- Exposure to blue light significantly decreased the viability of melanoma and endothelial cells, leading to cell death within 24 hours.
- Initial clinical application in a patient with melanoma metastasis showed promising results, including halted hemorrhage and tumor growth, suggesting blue light therapy could be an innovative treatment for skin cancers.
Objectives: To determine the role of the B-cell attracting chemokine CXCL-13, which may initiate B-cell trafficking and IgM production in diagnosing HAT meningo-encephalitis.
Methods: We determined CXCL-13 levels by ELISA on paired sera and CSF of 26 patients from Angola and of 16 controls (six endemic and ten non-endemic). Results were compared to standard stage determination markers and IgM intrathecal synthesis.
Trypanosoma brucei gambiense infection is an important public health challenge in sub-Saharan Africa. This parasitic disease is difficult to diagnose due to insidious clinical signs and transient parasitaemias. The clinical course is marked by two stages of increasing disease severity.
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- Human African trypanosomiasis (HAT) has two stages, with the second being potentially fatal without treatment, necessitating precise disease staging due to toxic treatments available.
- Recent research identifies specific antibodies (anti-NF and anti-GalC) in cerebrospinal fluid (CSF) as markers for central nervous system involvement, which can help in staging the disease.
- A dot enzyme-linked immunosorbent assay (dot-ELISA) to detect these antibodies was tested in Angola and the Central African Republic, achieving 83.2% sensitivity and 100% specificity, making it a promising tool for diagnosing CNS involvement in resource-limited settings.
Article Synopsis
- Trypanosomes invade the central nervous system during human African trypanosomiasis, but how they affect the blood-brain barrier is unclear.
- In laboratory studies, human bone marrow endothelial cells (HBMEC) showed activation in the presence of T. b. gambiense, indicated by changes in certain proteins and the production of inflammatory cytokines.
- The research suggests that soluble components from the trypanosomes, specifically variant surface glycoproteins (VSGs), are responsible for activating endothelial cells, potentially leading to increased inflammation, recruitment of immune cells, and compromised barriers that allow the parasites into the CNS.