Publications by authors named "Marie-Jeanne Pesant"
Article Synopsis
- * The tumor identified was a sex cord-stromal (granulosa cell) tumor, and the heifer's sex chromosome type was confirmed to be XX, indicating an ovotesticular disorder of sexual development with female characteristics.
- * This case highlights that while disorders of sexual development are common in mammals, the occurrence of gonadal tumors in these conditions is infrequent and has not been previously documented in cattle.
A necropsy was performed on a Common Raven () presenting an opportunistic fungal respiratory infection and a bursal lymphoid depletion with inclusion bodies, suggestive of a circovirus infection. High-throughput sequencing of circular DNA in the bursa of Fabricius revealed a complete genome sequence of a strain.
View Article and Find Full Text PDFThe effects of porcine circovirus type 2b (PCV2b) and porcine reproductive and respiratory syndrome virus (PRRSV) co-infection in epithelial cells of the swine respiratory tract is unknown. In the present study, the newborn pig trachea cell line NPTr-CD163, which is permissive to both viruses, was persistently infected with PCV2b and then with PRRSV. Viral replication, cell viability, cytokines' mRNA expression, and modulation of cellular genes expression were evaluated in infected cells.
View Article and Find Full Text PDFThe pathogenesis of porcine circovirus type 2b (PCV2b) and swine influenza A virus (SwIV) during co-infection in swine respiratory cells is poorly understood. To elucidate the impact of PCV2b/SwIV co-infection, newborn porcine tracheal epithelial cells (NPTr) and immortalized porcine alveolar macrophages (iPAM 3D4/21) were co-infected with PCV2b and SwIV (H1N1 or H3N2 genotype). Viral replication, cell viability and cytokine mRNA expression were determined and compared between single-infected and co-infected cells.
View Article and Find Full Text PDFArticle Synopsis
- PRRSV is a serious virus affecting swine, leading to significant economic losses, and no effective antiviral treatment currently exists.
- Previous research indicated that supernatants from Actinobacillus pleuropneumoniae (App) have antiviral properties against PRRSV and contain small, heat-resistant metabolites that are still unidentified.
- The current study successfully identified several adenosine nucleotide metabolites in App supernatant that reduce PRRSV infection in pig lung cells, suggesting that existing nucleoside analog drugs could be repurposed for PRRSV treatment.