Measuring intradialyser transmembrane and hydrostatic pressures: pitfalls and relevance in haemodialysis and haemodiafiltration.

Background: Post-dilutional haemodiafiltration (HDF) with high convection volumes (HCVs) could improve survival. HCV-HDF requires a significant pressure to be applied to the dialyser membrane. The aim of this study was to assess the pressure applied to the dialysers in HCV-HDF, evaluate the influence of transmembrane pressure (TMP) calculation methods on TMP values and check how they relate to the safety limits proposed by guidelines.

The CKD plasma lipidome varies with disease severity and outcome.

Background: Various alterations in lipid metabolism have been observed in patients with chronic kidney disease (CKD).

Objectives: To determine the levels of lipid species in plasma from CKD and hemodialysis (HD) patients and test their association with CKD severity and patient outcome.

Methods: Seventy-seven patients with CKD stage 2 to HD were grouped into classes of CKD severity at baseline and followed-up for 3.

Correction: Consequences of increasing convection onto patient care and protein removal in hemodialysis.

[This corrects the article DOI: 10.1371/journal.pone.

Geographical Variations in Blood Pressure Level and Seasonality in Hemodialysis Patients.

Seasons and climate influence the regulation of blood pressure (BP) in the general population and in hemodialysis patients. It is unknown whether this phenomenon varies across the world. Our objective was to estimate BP seasonality in hemodialysis patients from different geographical locations.

Consequences of increasing convection onto patient care and protein removal in hemodialysis.

Introduction: Recent randomised controlled trials suggest that on-line hemodiafiltration (OL-HDF) improves survival, provided that it reaches high convective volumes. However, there is scant information on the feasibility and the consequences of modifying convection volumes in clinics.

Methods: Twelve stable dialysis patients were treated with high-flux 1.

Early changes in body weight and blood pressure are associated with mortality in incident dialysis patients.

Background: While much research is devoted to identifying novel biomarkers, addressing the prognostic value of routinely measured clinical parameters is of great interest. We studied early blood pressure (BP) and body weight (BW) trajectories in incident haemodialysis patients and their association with all-cause mortality.

Methods: In a cohort of 357 incident patients, we obtained all records of BP and BW during the first 90 days on dialysis (over 12 800 observations) and analysed trajectories using penalized B-splines and mixed linear regression models.

The use of SDS-PAGE scanning of spent dialysate to assess uraemic toxin removal by dialysis.

Background: Uraemic toxins in the 8 to 60 kDa molecular weight range have been attracting increasing attention in dialysis therapy. However, there are no available standardized methods to evaluate their removal. Using new filtering membranes, we evaluated SDS-PAGE of spent dialysate to assess cut-off ranges and removal capacities into dialysate, while also measuring classical markers of dialyser function.

Use of spent dialysate analysis to estimate blood levels of uraemic solutes without blood sampling: urea.

Background: Urea kinetic modelling-based methods are widely used to assess dialysis efficacy. However, they require blood sampling and are susceptible to a number of errors, mainly from the calculated parameters (particularly V). Spent dialysate determinations have been used and have been shown to be reliable and simple to use.

Seasonal modifications in blood pressure are mainly related to interdialytic body weight gain in dialysis patients.

Background: Longitudinal studies in dialysis patients have identified seasonal variations in blood pressure that may follow climatic parameters such as external temperature and humidity. We aimed to assess the participation of interdialytic body weight gain variations in the seasonal profile of blood pressure.

Methods: Ninety-nine stable patients (40 F/59 M), 52.

Blood pressure is correlated with vitamin d(3) serum levels in dialysis patients.

Background/aims: The blood pressure, the most influencing factor in cardiovascular disease in end-stage renal failure patients, follows a seasonal variation during the year. Since vitamin D(3) is known to be related to sun exposure, we wanted to evaluate the putative participation of the vitamin D(3) metabolism in blood pressure modifications.

Methods: We studied 22 stable hemodialysis patients (11 females and 11 males, mean age +/- SD 56 +/- 1 year) who had been continuously treated in our dialysis unit for more than 1 year between 1994 and 1997 and did not receive pulse vitamin D(3) treatment.