Publications by authors named "Marie-Eve Routhier"
Article Synopsis
- - The ongoing phase II trial (NCT03363217) is investigating the effects of trametinib on pediatric low-grade gliomas (PLGG) and plexiform neurofibromas (PN), showing promising clinical responses and good tolerance in most patients.
- - Neurocognitive assessments were conducted on 36 patients with neurofibromatosis type 1 (NF1) before and after 72 weeks of trametinib treatment, revealing stable group performance but significant improvements in specific cognitive areas for some individuals.
- - The findings suggest that trametinib may have a positive impact on cognitive functioning in NF1 patients, particularly enhancing processing speed, visuo-motor skills, and verbal abilities, highlighting the need for neuro
Background: Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. Up to 50% will be refractory to conventional chemotherapy. It is now known that the majority of PLGG have activation of the MAPK/ERK pathway.
View Article and Find Full Text PDFBackground: Dexamethasone is more efficacious than prednisone in the treatment of acute lymphoblastic leukemia (ALL), but has also been associated with greater toxicity. We compared neuropsychological outcomes for patients treated on DFCI ALL Consortium Protocol 00-01, which included a randomized comparison of the two steroid preparations during post-induction therapy in children and adolescents with ALL.
Procedure: Between 2000 and 2005, 408 children with standard-risk or high-risk ALL treated on Dana-Farber Cancer Institute Consortium Protocol 00-01 were randomly assigned to prednisone or dexamethasone administered as 5-day pulses every 3 weeks for 2 years, beginning at week 7 of treatment.
Purpose: The aim of this study was to determine the performance profile of a group of children with cerebral palsy (CP) on the Wisconsin Card Sorting Test (WCST).
Methods: The sample consisted of 102 children aged between 9-12, divided into two groups: the clinical group consisted of 52 children with in mainstream class (37 with hemiplegia and 15 with diplegia), while the comparison group comprised 50 children matched for class, gender, age and socioeconomic status.
Results: The findings showed that children with CP make more non-perseverative errors, they completed fewer categories, required more trials to complete the first category and gave fewer conceptual responses than control children.