Publications by authors named "Marie-Eve Martineau-Dussault"
Introduction: The limbic system is critical for memory function and degenerates early in the Alzheimer's disease continuum. Whether obstructive sleep apnea (OSA) is associated with alterations in the limbic white matter tracts remains understudied.
Methods: Polysomnography, neurocognitive assessment, and brain magnetic resonance imaging (MRI) were performed in 126 individuals aged 55-86 years, including 70 cognitively unimpaired participants and 56 participants with mild cognitive impairment (MCI).
Study Objectives: Apolipoprotein E ɛ4 (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD). In addition, APOE4 carriers may exhibit sleep disturbances, but conflicting results have been reported, such that there is no clear consensus regarding which aspects of sleep are impacted. Our objective was to compare objective sleep architecture between APOE4 carriers and non-carriers, and to investigate the modulating impact of age, sex, cognitive status, and obstructive sleep apnea (OSA).
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- A study examined how obstructive sleep apnea (OSA) risk impacts cognitive decline and how this relationship varies with age and sex in middle-aged and older adults.* -
- Involving nearly 25,000 participants, the research used neuropsychological tests to measure cognitive changes over three years while assessing OSA risk through the STOP-B method.* -
- Results indicated that high OSA risk was linked to greater declines in cognitive functions like processing speed and attention, with older women experiencing unique memory decline.*
Background: Rapid-eye movement (REM) sleep highly depends on the activity of cholinergic basal forebrain (BF) neurons and is reduced in Alzheimer's disease. Here, we investigated the associations between the volume of BF nuclei and REM sleep characteristics, and the impact of cognitive status on these links, in late middle-aged and older participants.
Methods: Thirty-one cognitively healthy controls (66.
Article Synopsis
- Obstructive sleep apnea (OSA) is linked to cognitive decline and may affect functional connectivity (FC) between brain regions important for memory, particularly in older adults.
- Ninety-four participants underwent sleep assessments and neuropsychological tests to examine how OSA severity correlates with FC between the default mode network and medial temporal lobe regions, with results controlled for age, sex, and education.
- The study found that higher OSA severity measured by the apnea-hypopnea index is associated with reduced FC in specific brain areas, but these patterns did not correlate with oxygen desaturation or micro-arousal indices, and differences were noted based on cognitive status (MCI vs. unimpaired).
Medial temporal structures, namely the hippocampus, the entorhinal cortex and the parahippocampal gyrus, are particularly vulnerable to Alzheimer's disease and hypoxemia. Here, we tested the associations between obstructive sleep apnea (OSA) severity and medial temporal lobe volumes in 114 participants aged 55-86 years (35 % women). We also investigated the impact of sex, age, cognitive status, and free-water fraction correction on these associations.
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- Identifying individuals at risk for obstructive sleep apnea (OSA) is crucial for creating effective prevention and screening methods, particularly using data from a study with over 27,000 participants aged 45 and older.
- The overall prevalence of high-risk individuals was found to be 17.5%, with men at greater risk (21.9%) than women (13.1%), and specific factors like high C-reactive protein levels particularly affecting women.
- OSA risk is linked to age, various health issues (like cardiovascular diseases and diabetes), and for women, post-menopausal status, indicating that healthcare providers should prioritize OSA screening in their assessments.
Background: The association between obstructive sleep apnea and cognitive functioning is not yet fully understood and could be influenced by factors such as sex, age and systemic inflammation. We determined the sex- and age-specific association between obstructive sleep apnea risk and cognitive performance, and the influence of systemic inflammation on this association.
Methods: We included 25,899 participants from the Canadian Longitudinal Study of Aging comprehensive cohort, aged 45-85 years (51% women).
Article Synopsis
- About 40% of dementia risk can be linked to modifiable factors like physical inactivity, hypertension, diabetes, and obesity, with sleep disorders like obstructive sleep apnea (OSA) also considered a risk.
- Despite multiple studies, it's unclear whether OSA directly contributes to dementia risk, partly due to varying individual characteristics that might influence this relationship.
- Exploring factors such as age, sex, and lifestyle habits could help identify who is more at risk for cognitive decline in OSA patients, improving clinical management and treatment options, especially for those with mild OSA.
Obstructive Sleep Apnea and the Brain: a Focus on Gray and White Matter Structure.
Curr Neurol Neurosci Rep
February 2021
Purpose Of Review: Obstructive sleep apnea is extremely prevalent in the elderly and may precipitate dementia. We review recent advances on gray and white matter structure in obstructive sleep apnea, the impact of treatment, and potential pathological and neurodegenerative processes underlying brain structural changes.
Recent Findings: Two opposite patterns are observed in neuroimaging studies of obstructive sleep apnea.