Publications by authors named "Marie-Claude Lise"
Article Synopsis
- Bats can carry viruses that don't make them sick but can affect other animals.
- Researchers studied a type of bat called the common vampire bat to understand how they fight off viruses using special proteins called interferon.
- They discovered that this bat has different versions of a gene called OAS1 that helps in fighting viruses, and that these genes get activated even more when the bat's cells are exposed to a virus-like substance.
Though the common vampire bat, Desmodus rotundus, is known as the main rabies virus reservoir in Latin America, no tools are available to investigate its antiviral innate immune system. To characterize the IFN-I pathway, we established an immortalized cell line from a D. rotundus fetal lung named FLuDero.
View Article and Find Full Text PDFBackground: Neurotrophins play a central role in the development and maintenance of the nervous system. However, neurotrophins can also modulate B and T cell proliferation and activation, especially via autocrine loops. We hypothesized that both serum and lymphocytic neurotrophin levels may be deregulated in systemic Lupus erythematosus (SLE) and may reflect clinical symptoms of the disease.
View Article and Find Full Text PDFNeurotensin, a neuropeptide growth factor, and its two specific neurotensin receptors, NTSR1 and NTSR2, were shown to be expressed by human B cell lines. Another NTSR, sortilin, which is common to neurotensin and neurotrophins, was also detected as we have previously described. Neurotensin was functional in B cell lines; it induced their proliferation and inhibited apoptosis induced by serum deprivation or Fas activation.
View Article and Find Full Text PDFBackground: Diffuse large B-cell lymphoma (DLBCL) is a common and often fatal malignancy. Immunochemotherapy, a combination of rituximab to standard chemotherapy, has resulted in improved survival. However a substantial proportion of patients still fail to reach sustained remission.
View Article and Find Full Text PDFBackground: Neurotrophins (NTs) are able to activate lymphocytes and fibroblasts; they can modulate angiogenesis and sympathic vascular function. Thus, they can be implicated in the three pathogenic processes of systemic sclerosis (SSc). The aims of this study are to determine blood levels of Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) in SSc and to correlate them with clinical and biological data.
View Article and Find Full Text PDFArticle Synopsis
- BDNF (Brain-derived neurotrophic factor) acts as a growth factor and has been found to have an antiapoptotic effect, particularly in myeloma cells, and its secretion can be influenced by stress conditions.
- The study revealed that B cells can produce sortilin, a transport protein for BDNF, which plays a key role in the production and survival functions of BDNF under stress culture conditions.
- Increased BDNF production in mature B cell lines is linked to autocrine signaling and is important for understanding drug resistance in malignant B cells, while normal B cells also utilize sortilin and BDNF for survival and activation.