Comparative responses to nasal allergen challenge in allergic rhinitic subjects with or without asthma.

Background: Nasal allergen challenge (NAC) is useful to study the pathophysiology of rhinitis, and multiple challenges may more adequately approximate natural exposure.

Objective: To determine the effect of 4 consecutive daily NAC, on clinical and inflammatory parameters in rhinitics with or without asthma.

Methods: Rhinitic subjects were recruited: 19 with mild asthma and 13 without asthma.