Comparative study of second-line labor induction methods in patients with unfavorable cervix after first-line low-dose oral misoprostol.

Objective: The present study aimed to evaluate low-dose oral misoprostol induction, and compare different methods used in second-line induction in patients with a Bishop score less than 6.

Methods: This retrospective study analyzed the medical history and courses of pregnancy of all patients induced with first-line of low-dose oral misoprostol (50 μg every 4 h with a total of 200 μg/24 h) from April 2021 to June 2022 in a university hospital center, and reported outcomes according to the second-line method of induction.

Results: Among 437 labor inductions with low-dose oral misoprostol, 120 patients required a second-line induction.