Publications by authors named "Marie-Ange Calmejane"
Article Synopsis
- Adrenocortical carcinoma is a rare and serious type of cancer that affects the adrenal glands, and a specific bad version of it is called CIMP.
- Researchers found that CIMP is linked to certain proteins that change DNA in a way that makes the cancer worse and helps it escape the immune system.
- They think that using special treatments that change DNA could help make other cancer therapies work better for patients with this dangerous type of cancer.
Article Synopsis
- Cervical cancer is mostly caused by a virus called HPV, and people with advanced cancer have a higher chance of getting worse after treatment.
- Scientists studied blood samples from 94 patients to see if a specific part of HPV in the blood could help predict if their cancer would come back.
- They found that when the HPV DNA was cleared from the blood after treatment, patients had a better chance of staying cancer-free, while those who still had HPV DNA were more likely to relapse within about 10 months.
Adrenal cortex steroids are essential for body homeostasis, and adrenal insufficiency is a life-threatening condition. Adrenal endocrine activity is maintained through recruitment of subcapsular progenitor cells that follow a unidirectional differentiation path from zona glomerulosa to zona fasciculata (zF). Here, we show that this unidirectionality is ensured by the histone methyltransferase EZH2.
View Article and Find Full Text PDFSpecific human papillomavirus genotypes are associated with most ano-genital carcinomas and a large subset of oro-pharyngeal carcinomas. Human papillomavirus DNA is thus a tumour marker that can be detected in the blood of patients for clinical monitoring. However, data concerning circulating human papillomavirus DNA in cervical cancer patients has provided little clinical value, due to insufficient sensitivity of the assays used for the detection of small sized tumours.
View Article and Find Full Text PDFG-quadruplex structures (G4) are promising anticancerous targets. A great number of small molecules targeting these structures have already been identified through biophysical methods. In cellulo, some of them are able to target either telomeric DNA and/or some sequences involved in oncogene promotors, both resulting in cancer cell death.
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