Publications by authors named "Marie-Alix Derieppe"
Undifferentiated pleomorphic sarcoma (UPS) is the most frequent and the most aggressive sarcoma subtype for which therapeutic options are limited. The identification of new therapeutic strategies is therefore an important medical need. Epigenetic modifiers has been extensively investigated in recent years leading to the development of novel therapeutic agents.
View Article and Find Full Text PDFUnlabelled: Phosphatase of regenerating liver 2 (also known as PTP4A2) has been linked to cancer progression. Still, its exact role in glioblastoma (GBM), the most aggressive type of primary brain tumor, remains elusive. In this study, we report that pharmacologic treatment using JMS-053, a pan-phosphatase of regenerating liver inhibitor, inhibits GBM cell viability and spheroid growth.
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- Hepatocellular carcinoma (HCC) is linked to inflammation and can arise from liver diseases, leading to an increase in immunosuppressive myeloid cells, which complicates immunotherapy effectiveness.
- A detailed study of innate immune cells in HCC patients revealed an influx of inflammatory and myeloid cells, particularly a distinct type of THBS1 regulatory myeloid cells, which are associated with poor patient outcomes.
- THBS1 M cells, marked by specific gene expressions and characterized by their role in promoting tumor growth and immunosuppression, suggest that targeting these myeloid subsets could improve HCC immunotherapy strategies.
Purpose: Patients with advanced soft-tissue sarcomas (STS) exhibit a poor prognosis and have few therapeutic options. DNA-dependent protein kinase (DNA-PK) catalytic subunit is a multifunctional serine-threonine protein kinase that plays a crucial role in DNA double-strand damage repair via nonhomologous end joining.
Experimental Design: To investigate the therapeutic potential of DNA-PK targeting in STS, we first evaluated the prognostic value of DNA-PK expression in two large cohorts of patients with STS.
Article Synopsis
- Soft-tissue sarcoma (STS) is a rare and aggressive tumor type with a high fatality rate due to metastasis and poor treatment options.
- Researchers found that inhibiting the ATM signaling network can counteract resistance to the ATR inhibitor AZD6738, using CRISPR/Cas9 techniques to validate their findings.
- The combination of AZD6738 and ATM inhibitor AZD0156 significantly enhances the effectiveness of treatment, leading to increased DNA damage and tumor growth reduction in various STS types.
Lungs are the most frequent site of metastases growth. The amount and size of pulmonary metastases acquired from MRI imaging data are the important criteria to assess the efficacy of new drugs in preclinical models. While efficient solutions both for MR imaging and the downstream automatic segmentation have been proposed for human patients, both MRI lung imaging and segmentation in preclinical animal models remains challenging due to the physiological motion (respiratory and cardiac movements), to the low amount of protons in this organ and to the particular challenge of precise segmentation of metastases.
View Article and Find Full Text PDFLactate is a central metabolite in brain physiology but also contributes to tumor development. Glioblastoma (GB) is the most common and malignant primary brain tumor in adults, recognized by angiogenic and invasive growth, in addition to its altered metabolism. We show herein that lactate fuels GB anaplerosis by replenishing the tricarboxylic acid (TCA) cycle in absence of glucose.
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- - Radiosensitizing glioblastoma is crucial for improving survival rates, and this study investigates the effects of 5-aminolevulinic acid (5-ALA), which accumulates a metabolite called protoporphyrin IX (PpIX) with potential radiosensitization.
- - Using patient-derived tumor cell lines in a brain tumor model, the study tested different radiation therapy regimens, finding that while 5-ALA treatment was associated with significant PpIX accumulation, it did not enhance survival or inhibit tumor growth compared to radiation alone.
- - The findings indicate that in relevant glioblastoma models, 5-ALA does not boost the effectiveness of standard radiotherapy, showing no significant difference
Glioblastoma (GB) are the most frequent brain cancers. Aggressive growth and limited treatment options induce a median survival of 12-15 months. In addition to highly proliferative and invasive properties, GB cells show cancer-associated metabolic characteristics such as increased aerobic glycolysis.
View Article and Find Full Text PDFBackground: Despite the improvement of medulloblastoma (MB) treatments, survivors face severe long-term adverse effects and associated morbidity following multimodal treatments. Moreover, relapses are fatal within a few months. Therefore, chemotherapies inducing fewer adverse effects and/or improving survival at relapse are key for MB patients.
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- Obesity is increasing globally, and recent research highlights that fathers with poor diets can negatively impact their offspring's metabolic health.
- A study using mice demonstrated that multiple generations of fathers fed a Western diet led to increased fat mass and metabolic issues in their descendants, even when those offspring were fed a healthier diet.
- Interestingly, while these offspring developed an 'overweight' phenotype without certain metabolic diseases, sperm RNA injection studies indicate that while sperm RNA can trigger epigenetic changes related to metabolism, it does not sustain those changes over the long term.
The gene is amplified in dedifferentiated liposarcoma (DDLPS). Treatment with MDM2 antagonists is a promising strategy to treat DDLPS; however, drug resistance is a major limitation when these drugs are used as a single agent. This study examined the impact of MDM2 antagonists on the mitogen-activated protein kinase (MAPK) pathway in DDLPS and investigated the potential synergistic activity of a MAPK kinase (MEK) inhibitor in combination with MDM2 antagonists.
View Article and Find Full Text PDFPurpose: MDM2 and CDK4 are frequently co-amplified in well-differentiated/dedifferentiated liposarcoma (WDLPS/DDLPS). We aimed to determine whether combined MDM2/CDK4 targeting is associated with higher antitumour activity than a single agent in preclinical models of DDLPS.
Experimental Design: DDLPS cells were exposed to RG7388 (MDM2 antagonist) and palbociclib (CDK4 inhibitor), and apoptosis and signalling/survival pathway perturbations were monitored by flow cytometry and Western blotting.
Article Synopsis
- Researchers found that male mice fed a high-fat and high-sugar diet transmit obesity and diabetes traits to their offspring through RNA in sperm or testis, indicating a potential hereditary mechanism.
- Microinjections of sperm RNA from unhealthy males into embryos resulted in offspring exhibiting similar metabolic issues connected to the father's diet, while healthy RNA injections did not produce these effects.
- Notably, certain microRNAs, particularly miR19b, were overexpressed in the unhealthy males and could induce metabolic changes, suggesting that food-induced traits may be inherited through RNA signaling mechanisms.