Publications by authors named "Marie Schwebs"
Article Synopsis
- Maintenance of genome integrity is essential for accurate DNA transfer during cell division, with DNA polymerases (Pols) playing key roles in both genome replication and DNA damage repair.* -
- This study focuses on a specific translesion DNA polymerase, named TbPolIE, in African trypanosomes, revealing that its depletion causes slowed growth, altered DNA structure, and increased sensitivity to DNA damage.* -
- Additionally, the localization of TbPolIE at the nuclear periphery is linked to chromosome segregation issues and suggests its role in helping the parasite evade host immune responses through changes in surface protein gene regulation.*
During its life cycle, Trypanosoma brucei shuttles between a mammalian host and the tsetse fly vector. In the mammalian host, immune evasion of T. brucei bloodstream form (BSF) cells relies on antigenic variation, which includes monoallelic expression and periodic switching of variant surface glycoprotein (VSG) genes.
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