Publications by authors named "Marie S Evehe"
Article Synopsis
- The study investigates the effectiveness of different malaria diagnosis methods (presumptive diagnosis via temperature, SD Bioline™ rapid test, and light microscopy) in the Mutengene region of Cameroon, where presumptive diagnoses are often used due to challenges in confirming malaria cases.
- 320 participants' blood samples were analyzed through various methodologies, including PCR amplification for identifying malaria parasites, and diagnostic accuracy metrics (sensitivity and specificity) were calculated using PCR as a reference standard.
- Results indicated that the SD Bioline™ rapid test and light microscopy were highly sensitive and specific for malaria diagnosis, outperforming the presumptive diagnosis based on temperature, especially at higher parasite counts.
Background: As a result of the spread of parasites resistant to antimalarial drugs, Malaria treatment guidelines in Cameroon evolved from nonartemisinin monotherapy to artemisinin-based combination therapy. The aim of this study was to assess the effect of these therapy changes on the prevalence of molecular markers of resistance from 2003 to 2013 in Mutengene, Cameroon.
Methodology: Dry blood samples (collected in 2003-2005 and 2009-2013) were used for parasite DNA extraction.
Article Synopsis
- - The study compares the efficacy, tolerability, and safety of three malaria treatments for children under ten in Cameroon: artesunate-amodiaquine (ASAQ), artemether-lumefantrine (AL), and dihydroartemisinin piperaquine (DHAP), using a randomized controlled trial over a 42-day follow-up period.
- - Results showed that the PCR-corrected cure rates at day 42 were quite similar among the treatments: AL (96.7%), ASAQ (98.1%), and DHAP (96.3%), with no significant differences in parasite or fever clearance times, although the fever clearance patterns varied.
- - The study found that ASAQ and DHAP were