Publications by authors named "Marie Royer"
Adaptation mechanisms of Clostridioides difficile to auranofin and its impact on human gut microbiota.
NPJ Biofilms Microbiomes
September 2024
Article Synopsis
- * Research investigated how bacteria might develop resistance to AF, focusing on the role of the thioredoxin reductase enzyme (TrxB) and its multiple forms in clinical strains, though the number of TrxB genes didn't affect AF's minimum inhibitory concentration (MIC).
- * Mutations that arose after long-term exposure to AF were found in an anti-sigma factor, impacting bacterial physiology, and AF was shown to have a lesser effect on human gut microbiota compared to the antibiotic vancomycin.
Cells are unceasingly confronted by oxidative stresses that oxidize proteins on their cysteines. The thioredoxin (Trx) system, which is a ubiquitous system for thiol and protein repair, is composed of a thioredoxin (TrxA) and a thioredoxin reductase (TrxB). TrxAs reduce disulfide bonds of oxidized proteins and are then usually recycled by a single pleiotropic NAD(P)H-dependent TrxB (NTR).
View Article and Find Full Text PDFOxysterols found in oxidized low-density lipoproteins are probably involved in the appearance of atheroma; some are cytotoxic and some able to induce cytokine secretion. An oxysterol-induced interleukin-8 (IL-8) secretion in human monocytes/macrophages has been previously noticed, but the mechanisms remained unclear. In this paper, we investigated the signaling pathways leading to the induction of IL-8 secretion in monocytic THP-1 cells treated with 7beta-hydroxycholesterol, a cytototoxic oxysterol, or with 25-hydroxycholesterol, an oxysterol non-cytotoxic toward this cell line.
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