Publications by authors named "Marie Parrens"

Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus (EBV)-related neoplasm with male dominance and a poor prognosis. A better understanding of the genetic alterations and their functional roles in ENKTCL could help improve patient stratification and treatments. In this study, we performed a comprehensive genetic analysis of 178 ENKTCL cases to delineate the landscape of mutations, copy number alterations (CNA), and structural variations, identifying 34 driver genes including six previously unappreciated ones, namely, HLA-B, HLA-C, ROBO1, CD58, POT1, and MAP2K1.

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  • About 25% of patients with common variable immunodeficiency disease (CVID) have enlarged spleens (splenomegaly), which can impact their immune profiles, and this study analyzed 11 such patients before and after splenectomy (spleen removal).
  • In a larger cohort of 89 CVID patients, those with splenomegaly showed significant differences in immune cell types compared to those without, including lower counts of certain T cells and B cells and higher activation of CD4 and CD8 T cells.
  • Post-splenectomy, there was an increase in overall lymphocyte counts, mainly B lymphocytes and CD8 T cells, indicating that while the spleen's removal helps restore some immune
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Granulomatous disease is a serious complication of common variable immunodeficiency (CVID-GD) that occurs in 8-22% of these patients and can mimic sarcoidosis, with which it shares certain clinical, biological, and radiological features. However, few studies to date have compared the two pathologies immunologically and histologically. Therefore, we analyzed the immunological-histological findings for different tissue samples from ten patients with CVID-GD and compared them to those of biopsy-proven sarcoidosis.

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Distinguishing between follicular lymphoma (FL) and nodal marginal zone lymphoma (NMZL) can be difficult when morphologic and phenotypic features are unusual and characteristic cytogenetic rearrangements are absent. We evaluated the diagnostic contribution of ancillary techniques-including fluorescence in situ hybridization (FISH)-detected 1p36 deletion; reverse-transcriptase, multiplex, ligation-dependent probe amplification (RT-MLPA); and next-generation sequencing (NGS)-for tumors that remain unclassified according to standard criteria. After review, 50 CD5-negative small B-cell lymphoid neoplasms without BCL2 and BCL6 FISH rearrangements were diagnosed as FLs (n = 27), NMZLs (n = 5), or unclassified (n = 18) based on the 2016 World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues.

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Mature tertiary lymphoid structures (mTLSs) are organized lymphoid structures containing B lymphocytes admixed to CD23+ follicular dendritic cells. Their presence has been linked to improved survival and sensitivity to immune checkpoint inhibitors in several cancers, emerging as a promising pancancer biomarker. However, the requirements for any biomarker are clear methodology, proven feasibility, and reliability.

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  • ALK-negative anaplastic large cell lymphoma (ALCL) has subgroups based on gene rearrangements, specifically DUSP22-R and TP63-R, which show different survival rates, making the impact of DUSP22 results unclear.
  • In a study involving 104 newly diagnosed ALCL patients, 45% showed DUSP22-R, indicating that tumors with this rearrangement had different characteristics, including more CD3 expression and more frequent bone involvement.
  • The 5-year progression-free survival (PFS) was significantly higher in patients with DUSP22-R compared to those without, and while both performance status and DUSP22 status affected PFS, only performance status influenced overall survival (OS); patients receiving brent
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According to expert guidelines, lymph node surgical excision is the standard of care for lymphoma diagnosis. However, core needle biopsy (CNB) has become widely accepted as part of the lymphoma diagnostic workup over the past decades. The aim of this study was to present the largest multicenter inventory of lymph nodes sampled either by CNB or surgical excision in patients with suspected lymphoma and to compare their diagnostic performance in routine pathologic practice.

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  • The overview discusses the upcoming 5th edition of the WHO Classification of Haematolymphoid Tumours, specifically focusing on lymphoid neoplasms, while myeloid and histiocytic neoplasms will be covered separately.
  • Key changes from the previous 4th edition include a hierarchical reorganization of entities, modifications in their nomenclature, and revisions to diagnostic criteria and subtypes.
  • The new edition will also see the deletion of certain entities, the introduction of new ones, and the inclusion of tumour-like lesions and germline predisposition syndromes related to lymphoid neoplasms.
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  • Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is an aggressive, rare form of T-cell lymphoma mainly found in Asia, with a clinical study conducted on 71 European patients showing a median age of 67 years.
  • Most patients had gastrointestinal symptoms requiring emergency surgery, with around 40% diagnosed at stage IV, and tumors were classified into typical and atypical morphologies sharing similar immunophenotypic profiles.
  • The study highlighted significant genetic alterations, including mutations in genes like MYC, STAT5B, and TP53, which are associated with poor survival outcomes and treatment resistance, indicating the high clinical risk of MEITL.
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Background: Intravascular large B-cell lymphoma (lVLBCL) is a very rare type of large B-cell lymphoma.

Methods: We conducted a retrospective study on IVLBCL patients treated from 2000 to 2016 in LYSA cooperative group centers.

Results: Sixty-five patients were identified in 23 centers.

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Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma is a variant of follicular dendritic cell neoplasm most often arising in the liver or spleen. Two histological patterns can be identified in this variant, namely a granulomatous and an eosinophil-rich one. We present the case of a 69-year-old woman with a splenic mass.

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  • Primary cutaneous large B-cell lymphomas (PCLBCL) are hard to diagnose because they come in different types that need different treatments and have different outcomes.
  • Scientists studied 55 PCLBCL cases and found many were classified as either germinal center (GC) or non-GC types, with some unclassified ones needing more testing.
  • They used a special test called RT-MLPA to accurately sort out the different types of PCLBCL, which could help doctors better figure out how to treat patients based on their specific lymphoma type.
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Nodal peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) with cytotoxic phenotype is overall rare, with most reports coming from Asia. Given its elusive pathobiology, we undertook a clinicopathological and molecular study of 54 Western patients diagnosed with PTCL, NOS expressing cytotoxic molecules, within a lymph node. More commonly males (M/F-2,6/1) with median age of 60 years were affected.

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Purpose: The AHL2011 study (ClinicalTrials.gov identifier: NCT01358747) demonstrated that a positron emission tomography (PET)-driven de-escalation strategy after two cycles of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) provides similar progression-free survival (PFS) and overall survival (OS) and reduces early toxicity compared with a nonmonitored standard treatment. Here, we report, with a prolonged follow-up, the final study results.

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Despite the impressive efficacy of chimeric antigen receptor (CAR) T-cell therapy (CART) in B-cell non-Hodgkin lymphomas, durable responses are uncommon. The histopathologic and molecular features associated with treatment failure are still largely unknown. Therefore, we have analyzed 19 sequential tumor samples from 9 patients, prior anti-CD19 CART (pre-CART) and at relapse (post-CART), using immunohistochemistry, fluorescence in situ hybridization, array comparative genomic hybridization, next-generation DNA and RNA sequencing, and genome-scale DNA methylation.

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In this retrospective study, we report 70 cases of Epstein-Barr virus (EBV)+ diffuse large B-cell lymphoma not otherwise specified (DLBCL-NOS) among 1696 DLBCL-NOS cases diagnosed between 2006 and 2019 (prevalence of 4.1%). At diagnosis, median age was 68.

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Although follicular lymphoma (FL) is usually graded as FL1-2, FL3A, and FL3B, some borderline cases can be observed and led us to investigate the clinicopathologic diversity of grade 3 FL (FL3). Among 2449 FL patients enrolled in Lymphoma Study Association (LYSA) trials, 1921 cases with sufficient material underwent a central pathologic review. The resulting diagnoses comprised 89.

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  • The study examines the complex genetic factors behind peripheral T-cell lymphoma (PTCL) and introduces a new multiplex ligation-dependent RT-PCR assay for detecting 33 associated fusion transcripts simultaneously, which is crucial since current detection methods are costly and slow.
  • The assay successfully identified anaplastic lymphoma kinase (ALK) fusions in most ALK-positive cases, and also revealed several non-ALK fusion transcripts mainly derived from follicular helper T-cells in various PTCL samples.
  • The method's effectiveness was confirmed using traditional RT-PCR and Sanger sequencing, highlighting its potential as a reliable tool for analyzing these diverse lymphomas in clinical settings.
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  • MYD88 activating mutations are commonly found in Waldenström macroglobulinemia (WM) and aggressive B-cell lymphomas, indicating their role in these diseases.
  • A new mouse model was created to study MYD88 activation, showing that it leads to increased IgM levels, spleen enlargement, and a progression from polyclonal to monoclonal immunoglobulins as the mice age.
  • Transcriptomic analysis of the Myd88 mice revealed a link between MYD88 activation, tumor proliferation, and features similar to those found in WM, suggesting a shared biological mechanism.
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BCR-ABL-fusion-negative myeloproliferative neoplasms (MPNs) with myelofibrosis (MF) include primary MF, post-polycythemia vera MF and post-essential thrombocythemia MF. Clonal extramedullary hematopoiesis (EMH) can occur during MPN pathogenesis. Although histopathological bone-marrow (BM) features during clonal EMH have been investigated, those of the spleen have been poorly described.

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Angioimmunoblastic T-cell lymphoma (AITL) is a frequent T-cell lymphoma in the elderly population that has a poor prognosis when treated with cyclophosphamide, doxorubicin, vincristine, and prednisone  (CHOP) therapy. Lenalidomide, which has been safely combined with CHOP to treat B-cell lymphoma, has shown efficacy as a single agent in AITL treatment. We performed a multicentric phase 2 trial combining 25 mg lenalidomide daily for 14 days per cycle with 8 cycles of CHOP21 in previously untreated AITL patients aged 60 to 80 years.

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Background: Classification of thymic epithelial tumours (TETs) is known to be challenging; however, the level of discordances at a nationwide level between initial and expert diagnosis and their clinical consequences are currently unknown. RYTHMIC is a national network dedicated to the management of TET based on initial histological diagnosis, followed by an additional expert review of all cases. Our aim was to evaluate the discordances between initial and expert diagnoses and whether they would have led to different clinical management.

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The RYTHMIC network, supported by the French National Cancer Institute is dedicated to the management of patients with thymic epithelial tumors through regional and national multidisciplinary tumor boards. Tumor board decisions are based on the initial pathology diagnoses. However, following clinical inclusion in the network, a central pathology review is organized, implicating a panel of pathologists, for histotype and stage classification, which is different from a classical second opinion from pathologist to pathologist for a difficult case.

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