The prognosis of schizophrenia: A systematic review and meta-analysis with meta-regression of 20-year follow-up studies.

Objective: The aim was to examine the general outcome of schizophrenia after 20 years or more.

Methods: Using the PRISMA guidelines, we conducted a systematic review and meta-analysis with meta-regression on long-term follow-up studies of schizophrenia up until April 21, 2021. We included prospective studies with at least 20 years of follow-up on patients with a diagnosis of schizophrenia, and the studies had to include face-to-face clinical evaluation.