Publications by authors named "Marie Noelle Delyfer"
Article Synopsis
- The study investigated the link between air pollution and cataract surgery incidence in older adults in Bordeaux, France.
- Researchers followed 829 participants aged 65 and older from 1999-2017, monitoring their cataract surgeries and estimating their long-term air pollution exposure.
- Results showed that long-term exposure to nitrogen dioxide (NO) at levels ≥40 μg/m was significantly associated with increased incidence of cataract surgery, suggesting that meeting air quality standards could benefit public health.
Article Synopsis
- Age-related macular degeneration (AMD) is a complex eye disease influenced by both genetic factors and involves a subtype called reticular pseudodrusen (RPD), which increases the risk of severe vision loss.* -
- A genome-wide association study compared genetic data from individuals with AMD and/or RPD to controls, finding significant associations specifically on chromosome 10, while chromosome 1 did not show this correlation in RPD cases.* -
- The chromosome 10 region includes a long non-coding RNA related to retinal health, highlighting its potential role in retinal thickness and influencing the outer segment of photoreceptors.*
Purpose: Lipopolysaccharide (LPS)-type endotoxins are naturally found in the gut microbiota and there is emerging evidence linking gut microbiota and neuroinflammation leading to retinal neurodegeneration. Thinning of the retinal nerve fiber layer (RNFL) is a biomarker of retinal neurodegeneration, and a hallmark of glaucoma, the second leading cause of blindness worldwide. We assessed the association of a blood biomarker of LPS with peripapillary RNFL thickness (RNFLT) and its longitudinal evolution up to 11 years.
View Article and Find Full Text PDF: The aim of the study was to compare dacryocystectomy (DCT) versus dacryocystorhinostomy (DCR) in patients with dacryocystitis in terms of tearing complaints. : We conducted a retrospective and comparative study on 19 patients. The main outcome measure was defined as an improvement by 1 point of the Munk score postoperatively.
View Article and Find Full Text PDFPurpose: To assess the efficacy and safety of 0.19-mg fluocinolone acetonide (FAc) intravitreal implant (Iluvien) in treating chronic postoperative cystoid macular edema (PCME) after pars plana vitrectomy.
Design: Retrospective multicentric case series in clinical settings.
Objective: To investigate the associations between circulating vitamins A, D, E, B6, B9, B12 and longitudinal changes in retinal nerve fiber layer (RNFL) thickness.
Methods: The Alienor study, a prospective population-based cohort (Bordeaux, France), includes 963 individuals aged 73 years or older at baseline. The present study included 646 participants with complete RNFL measurement and vitamins.
Photocoagulation or sham laser in addition to conventional anti-VEGF therapy in macular edema associated with TelCaps due to diabetic macular edema or retinal vein occlusion (TalaDME): a study protocol for a multicentric, French, two-group, non-commercial, active-control, observer-masked, non-inferiority, randomized controlled clinical trial.
Trials
April 2024
Article Synopsis
- Macular edema (ME) occurs due to leakage from retinal blood vessels, which can lead to serious vision loss, and current treatments like intravitreal injections (IVIs) are costly and burdensome.
- The TalaDME study investigates whether a targeted laser treatment (ICG-guided targeted laser - IGTL) combined with standard IVI reduces the number of injections needed within the first year while maintaining visual acuity.
- This French multicentric trial involves 270 patients with ME linked to diabetic retinopathy or retinal vein occlusion, randomly assigning them to either standard care or the combined treatment to evaluate the effectiveness of laser photocoagulation on reducing injection frequency and improving visual outcomes.
Purpose: To evaluate the safety and efficacy of the fluocinolone acetonide implant (FAi, Iluvien Horus pharma, Nice, France) in non-infectious uveitic macular edema (UME) and to approach the predictive factors of treatment response.
Methods: This retrospective, multicenter real-life study included patients with chronic non-infectious UME who received intravitreal FAi after at least two dexamethasone implants (DEXi).
Results: Twenty-six eyes from 22 patients (73.
Objective: This study aimed to develop a deep learning (DL) model, named 'DeepAlienorNet', to automatically extract clinical signs of age-related macular degeneration (AMD) from colour fundus photography (CFP).
Methods And Analysis: The ALIENOR Study is a cohort of French individuals 77 years of age or older. A multi-label DL model was developed to grade the presence of 7 clinical signs: large soft drusen (>125 μm), intermediate soft (63-125 μm), large area of soft drusen (total area >500 μm), presence of central soft drusen (large or intermediate), hyperpigmentation, hypopigmentation, and advanced AMD (defined as neovascular or atrophic AMD).
Purpose: To test the hypothesis that central drusen location is strongly linked with known Age-related Macular Degeneration (AMD) risk factors and risk of incident late AMD.
Methods: The Alienor study is a prospective population-based cohort study of residents of Bordeaux, France, followed from 2009 to 2017. On retinal photographs, we defined central drusen as at least one soft drusen (>63 μm) within 500 μm from fovea and pericentral drusen as at least one drusen 500-3000 μm from fovea, in the absence of any central drusen.
Purpose: To investigate the link between lifelong exposure to ultraviolet radiation (UVR) and the development of age-related macular degeneration (AMD).
Methods: The Alienor study is a prospective population-based cohort involving 963 residents of Bordeaux, France, older than 73 years. A subset of 614 participants for advanced AMD and 422 participants for early AMD were included in the analysis.
Article Synopsis
- Chronic inflammation and oxidative stress are key factors in age-related macular degeneration (AMD), and lipopolysaccharide (LPS) from gut bacteria may contribute to its development.
- A study involving 963 elderly participants in Bordeaux measured blood levels of esterified 3-hydroxy fatty acids (3-OH FAs) to assess LPS exposure and its link to AMD.
- Results indicated that higher levels of 3-OH FAs were significantly associated with an increased risk of developing early AMD, but not advanced AMD, suggesting LPS exposure could play a role in the early stages of the disease.
Introduction: We explored the longitudinal relationship between retinal vascular features and dementia incidence over 10 years.
Methods: Among 584 participants from the Three-City-Alienor (3C-Alienor) population-based cohort, quantitative retinal vascular features (caliber, tortuosity, fractal dimension) were measured using semi-automated software. Dementia was actively diagnosed over the follow-up period.
Article Synopsis
- The study focuses on albinism, a genetic condition where melanin production is affected, highlighting the variability in its forms and their impact on ocular health.
- A retrospective analysis was performed on 127 patients with oculocutaneous albinism from a specific hospital in France, assessing their genetic data and visual acuity.
- The findings revealed no significant differences in visual acuity across the main forms of albinism, but significant differences in ametropia were observed, along with a high prevalence of grade 4 foveal hypoplasia among patients, independent of the gene involved.
Introduction: There is little understanding of long-term treatment persistence in patients receiving anti-vascular endothelial growth factor (anti-VEGF) injections for diabetic macular edema (DME), particularly relating to treatment intervals. The aim of this study was to investigate the association between treatment interval and discontinuation rate after 24 months of unilateral anti-VEGF treatment in patients with DME under routine clinical care in the USA.
Methods: This was a non-interventional, retrospective cohort study to review the health insurance claims of adults with DME linked with the IBM MarketScan Commercial and Medicare Supplemental databases, who were continuously enrolled in a health plan for at least 6 months prior to their first anti-VEGF treatment and for a duration of at least 24 months between July 2011 and June 2017.
Chronic exposure to air pollution may have adverse effects on neurodegenerative diseases. Glaucoma, the second leading cause of blindness worldwide, is a neurodegenerative disease of the optic nerve, characterized by progressive thinning of the retinal nerve fiber layer (RNFL). We investigated the relationship of air pollution exposure with longitudinal changes of RNFL thickness in the Alienor study, a population-based cohort of residents of Bordeaux, France, aged 75 years or more.
View Article and Find Full Text PDFPurpose: To compare the efficacy and the safety of submacular hemorrhage (SMH) management using either surgical pars plana vitrectomy (PPV) or pneumatic displacement (PD) with tissue plasminogen activator (tPA) and vascular endothelial growth factor (VEGF) inhibitor added to each arm.
Design: Randomized, open-label, multicenter superiority study.
Participants: Ninety patients with neovascular age-related macular degeneration (nAMD) 50 years of age or older with recent SMH (≤ 14 days) of more than 2 optic disc areas and predominantly overlying the retinal pigment epithelium.
Aims: We investigated whether Diabetic Retinopathy (DR) is related to Diabetic Foot Ulcer (DFU) development, adjusted for the stratification of the International Work Group on Diabetic Foot (IWGDF) guidance.
Materials And Methods: DR and IWGDF stratification was registered retrospectively in patients hospitalised from 2009 to 2017 for uncontrolled and/or complicated type 2 diabetes. New DFUs were registered until 2020.
Article Synopsis
- Macular edema affects about 20% of people with retinitis pigmentosa (RP) and can impair central vision, with corticosteroid injections showing effectiveness in treatment.
- A case study outlines a 34-year-old woman with persistent macular edema who had previously not responded to other treatments and found success with a fluocinolone acetonide implant.
- The results indicate that fluocinolone acetonide could be a promising treatment option for patients with persistent, steroid-dependent macular edema associated with RP.
To assess anatomical and functional outcomes after switching from dexamethasone implant (DEXi) to fluocinolone acetonide implant (FAci) in 113 diabetic macular edema eyes, a multicentric retrospective observational study was conducted. Seventy-five eyes (73.5%) were switched 1−8 weeks after their last DEXi.
View Article and Find Full Text PDFB vitamins may protect against age-related macular degeneration (AMD). We evaluated the associations of dietary intake and serum vitamins with the incidence of advanced AMD in the Alienor study. The Alienor study is a prospective population-based cohort of 963 residents of Bordeaux, France, who were 73 years or older at baseline (2006-2008).
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