Publications by authors named "Marie Noelle Crepy"
Background: The lack of attention to Chronic Hand Eczema (CHE) and the lack of a specific International Classification of Diseases code for CHE may have limited the assessment of CHE prevalence. To date, prevalence estimates have primarily been derived from (partly small) single-country studies.
Objectives: To estimate the annual prevalence of self-reported physician-diagnosed CHE across socio-demographic characteristics among adults in Canada, France, Germany, Italy, Spain, and the United Kingdom (UK).
Article Synopsis
- Octylisothiazolinone (OIT) is a biocide used in leather products, raising concerns about allergic reactions, particularly in headphones.
- A study reported cases of allergic contact dermatitis (ACD) in patients linked to headphones containing OIT, confirming its strong allergic potential through patch testing and chemical analysis.
- The findings suggest that OIT is a significant sensitizer and highlight the need for safer use guidelines and improved product labeling in the leather industry to protect consumers.
Article Synopsis
- Chronic hand eczema is a painful, inflammatory condition affecting the hands and wrists, impacting patients' quality of life and ability to work; the DELTA 1 and DELTA 2 trials aimed to evaluate the effectiveness and safety of delgocitinib cream against a placebo.* -
- Both studies were randomized, double-blind, and involved adult participants with moderate to severe chronic hand eczema, comparing the effects of twice-daily applications of delgocitinib cream to a placebo for 16 weeks, focusing on achieving a clear or almost clear skin condition.* -
- Results showed that significantly more patients treated with delgocitinib achieved treatment success compared to the placebo group, with notable differences observed in both trials
Patch testing is the only clinically applicable diagnostic method for Type IV allergy. The availability of Type IV patch test (PT) allergens in Europe, however, is currently scarce. This severely compromises adequate diagnostics of contact allergy, leading to serious consequences for the affected patients.
View Article and Find Full Text PDFThe impact of chronic urticaria on work has been scarcely reported, whereas its peak incidence is between the ages of 20 and 40. The aim of this study was to assess the occupational impact of chronic urticaria and its treatment, by combining objective and patient-reported data. A monocentric observational study was performed using questionnaires over a 1-year period from 2021 to 2022 in chronic urticaria patients who were in a period of professional activity and agreed to participate.
View Article and Find Full Text PDFBackground: Limited and conflicting data have been reported on the impact of dupilumab (DUPI) on patch test (PT) results and its efficacy against allergic contact dermatitis (ACD).
Objective: This study was undertaken to analyze PT reactivities and relevance during treatment with DUPI to determine whether they could detect ACD in patients with uncontrolled or worsened atopic dermatitis (AD) who were receiving this agent.
Methods: This prospective, multicenter study examined 76 DUPI-treated patients who had undergone PTs.
Objective: To analyse the clinical characteristics and sensitivity of an essential oil patch test series (EOS) in patients sensitized to their own essential oils (EOs).
Method: We analysed the clinical data and patch test results obtained with the European baseline series (BSE) and an EOS, as well as the mode of use of EOs, through a questionnaire included in the patient file.
Results: The study included 42 patients (79% women, average age 50 years) with allergic contact dermatitis (ACD), 8 patients required hospitalization.
Hand eczema in glove-wearing patients.
Contact Dermatitis
September 2023
Background: Allergic contact dermatitis to gloves is mostly induced by rubber accelerators. The European baseline series (EBS) appears insufficient to detect glove allergy. Since 2017, it is recommended to use the European rubber series (ERS) and to test the patients' own gloves.
View Article and Find Full Text PDFArticle Synopsis
- * Research involving gene expression profiling of skin biopsies from DI-Pso patients revealed significant activation of the T helper 17/IL-23 pathways, alongside increased IL-36 expression, which is a marker of pustular psoriasis.
- * The findings indicate a shift in immune response from T helper 2 to T helper 17 in DI-Pso cases, coupled with notable skin barrier dysfunction compared to healthy individuals and those with other skin conditions.
Dermatoses are among the most frequent diseases related to working conditions. Nevertheless, there is an under-reporting of occupational diseases and the management of patients with either a possible occupational dermatosis or a condition aggravated by work which could be improved. The aim of this article is to present the most common occupational dermatoses, a multidisciplinary diagnostic approach to them and to propose a screening tool for occupational exposures.
View Article and Find Full Text PDFBackground And Objectives: The repeated open application test (ROAT) is an adjuvant investigation measure to patch testing in the diagnosis of allergic contact dermatitis. ESCD recommends a 15 days duration but its overall duration varies according to publications and patients hardly adhere to prolonged ROAT duration beyond 1 week.
Materials And Methods: The Dermatology and Allergy Group of the French Society of Dermatology performed a prospective study with the aim of determining the best duration for the ROAT.
Article Synopsis
- Hand eczema is a widespread inflammatory skin condition, which necessitates up-to-date treatment information for healthcare providers.
- The European Society of Contact Dermatitis aimed to refresh their guidelines on the diagnosis, prevention, and treatment of hand eczema through a committee that reviewed the latest evidence and created new consensus strategies.
- The updated guidelines are expected to enhance the way hand eczema is managed by healthcare professionals.
Few cases of skin diseases caused by exposure to artichokes have been published. Artichokes contain sesquiterpene lactones, which are known to be sensitizing. Irritant contact dermatitis (ICD) has also been diagnosed.
View Article and Find Full Text PDFBackground: There is currently no agreed cosmetic series for use across Europe.
Objectives: To establish allergens currently tested in local and national cosmetic series.
Method: Members of the European Surveillance System on Contact Allergy and the European Cooperation in Science and Technology project TD1206 ("StanDerm") were surveyed to establish their current practice.
Background: Assessment of the clinical relevance of patch test reactions is an essential part of the diagnostic work-up of patients with (occupational) contact dermatitis. However, final diagnostic information, particularly the clinical relevance of allergic patch test reactions, has hitherto been ill-represented in clinical documentation systems (patch test software) and surveillance registries based on these.
Objectives: To develop, implement as a pilot study, and analyse concerning feasibility and contents a new concept of representing the full scope of diagnostic information utilized in the diagnosis of patients with (occupational) contact dermatitis.
Background: Irritant exposure may be a contributory cause or the sole cause of (occupational) hand dermatitis. However, the documentation of irritant exposures in clinical practice is not standardized.
Objectives: To examine the feasibility and usefulness of a form with different items addressing both occupational and non-occupational irritant exposures in a semiquantitative way.
Background: Accelerators in rubber gloves constitute an important group of contact allergens, particularly in healthcare workers.
Objectives: To assess the efficacy of accelerator-free medical gloves in the secondary prevention of allergic contact dermatitis caused by rubber accelerators in healthcare workers.
Methods: Nine healthcare workers with hand eczema were advised to use accelerator-free rubber gloves after a diagnosis of allergic contact dermatitis caused by rubber accelerators.