Publications by authors named "Marie Neergaard Harder"

Article Synopsis
  • Physical activity (PA) can influence genetic factors linked to obesity, leading to a deeper understanding of how genetics and lifestyle interact in shaping body fat.
  • A study involving over 200,000 adults analyzed the relationship between PA and various obesity-related measurements, confirming that the impact of the FTO gene is reduced in physically active individuals.
  • The research also discovered 11 new genetic regions associated with body fat, indicating that considering lifestyle factors like PA can help uncover more genetic links to obesity.
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Article Synopsis
  • Many genome-wide association studies (GWAS) often overlook environmental factors like smoking, which might affect the genetic analysis of obesity traits.
  • This study analyzed GWAS data from over 240,000 participants, including smokers and nonsmokers, to find genetic links to body mass index (BMI) and body fat distribution.
  • The researchers identified 23 new genetic loci related to obesity and 9 loci that interact with smoking, suggesting that smoking can influence genetic predispositions to body fat.
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Article Synopsis
  • * Our method calculated averaged principal components (AvPCs) that represent body shape, with the first four AvPCs accounting for over 99% of the variability and showing heritability linked to cardiometabolic outcomes.
  • * We conducted genome-wide association studies across 65 studies and identified six new genetic loci associated with different AvPCs, emphasizing that analyzing multiple traits can uncover complex genetic factors that single-trait analyses might miss.
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Objectives: A trans-ethnic meta-analysis of type 2 diabetes genome-wide association studies has identified seven novel susceptibility variants in or near TMEM154, SSR1/RREB1, FAF1, POU5F1/TCF19, LPP, ARL15 and ABCB9/MPHOSPH9. The aim of our study was to investigate associations between these novel risk variants and type 2 diabetes and pre-diabetic traits in a Danish population-based study with measurements of plasma glucose and serum insulin after an oral glucose tolerance test in order to elaborate on the physiological impact of the variants.

Methods: Case-control analyses were performed in up to 5,777 patients with type 2 diabetes and 7,956 individuals with normal fasting glucose levels.

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Aims: A study of 222 candidate genes in type 2 diabetes reported association of variants in RAPGEF1, ENPP1, TP53, NRF1, SLC2A2, SLC2A4 and FOXC2 with type 2 diabetes in 4,805 Finnish individuals. We aimed to replicate these associations in a Danish case-control study and to substantiate any replicated associations in meta-analyses. Furthermore, we evaluated the impact on diabetes-related intermediate traits in a population-based sample of middle-aged Danes.

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