Publications by authors named "Marie N'diaye"
Pattern recognition receptors (PRRs) are crucial for responses to infections and tissue damage; however, their role in autoimmunity is less clear. Herein we demonstrate that 2 C-type lectin receptors (CLRs) Mcl and Mincle play an important role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Congenic rats expressing lower levels of Mcl and Mincle on myeloid cells exhibited a drastic reduction in EAE incidence.
View Article and Find Full Text PDFArticle Synopsis
- - Vitamin D has shown protective effects against experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS), by reducing the proliferation of certain immune cells, specifically CD4+ T cells and pathogenic Th17 cells.
- - The study reveals that vitamin D influences critical signaling pathways related to T-cell activation and differentiation (such as Jak/Stat and PI3K/Akt), along with causing epigenetic changes, including alterations in DNA methylation and histone modifications.
- - Treatment with vitamin D led to a decrease in the frequency of harmful T-cell subsets and affected gene expression related to MS risk, suggesting that vitamin D supplementation might impact the development of MS in susceptible individuals.
Post-translational modifications of autoantigens are hypothesized to affect their immunogenicity. We here report that nitration of tyrosine 40 in Myelin Oligodendrocyte Glycoprotein (MOG) abrogates its encephalitogenicity both at protein and peptide levels in the experimental autoimmune encephalomyelitis (EAE) model in H2 C57BL/6 mice. Furthermore, nitrated MOG displays inferior antigen-specific proliferation of 2D2 splenocytes in vitro.
View Article and Find Full Text PDFMultiple sclerosis (MS) is a complex autoimmune condition with firmly established genetic and environmental components. Genome-wide association studies (GWAS) have revealed a large number of genetic polymorphisms in the vicinity of, and within, genes that associate to disease. However, the significance of these single-nucleotide polymorphisms in disease and possible mechanisms of action remain, with a few exceptions, to be established.
View Article and Find Full Text PDFArticle Synopsis
- Dendritic cells are key players in the immune system, and researchers often utilize bone marrow-derived dendritic cells due to the limited availability of natural ones.
- A comparison between cells derived from GM-CSF/IL-4 and FLT3 ligand showed distinct differences in their surface markers, function, and secreted cytokines.
- The FLT3 ligand-derived dendritic cells excelled in antigen presentation and T cell stimulation, while GM-CSF/IL-4-derived cells were better at phagocytosis and promoting regulatory T cells, demonstrating their functional differences.
Background: Ιn multiple sclerosis (MS), axonal damage leads to permanent neurological disabilities and the spreading of the autoimmune response to axonal antigens is implicated in disease progression. Experimental autoimmune encephalomyelitis (EAE) provides an animal model that mimics MS. Using different EAE models, we investigated the pathophysiological basis of epitope spreading to neurofascin, a protein localized at the node of Ranvier and its regulation by non-MHC genes.
View Article and Find Full Text PDFLactococcus lactis is a non-pathogenic and non-colonizing Gram-positive bacterium commonly used in the dairy industry. To support the potential applications of this bacterium, such as use as an oral live vaccine, it is of interest to investigate the adjuvant properties of L. lactis.
View Article and Find Full Text PDF