Publications by authors named "Marie Miquel"
HIV infects the central nervous system (CNS) during primary infection and persists in resident macrophages. CNS infection initiates a strong local immune response that fails to control the virus but is responsible for by-stander lesions involved in neurocognitive disorders. Although highly active anti-retroviral therapy now offers an almost complete control of CNS viral proliferation, low-grade CNS inflammation persists.
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- Progressive multifocal leukoencephalopathy (PML) is a serious risk associated with the use of natalizumab (NAT) for treating relapsing multiple sclerosis (MS).
- JC virus serology is a key risk factor for developing PML, and monitoring this status is critical for patients on NAT.
- If a patient shows seroconversion, careful consideration is required before discontinuing NAT to prevent a rebound of MS symptoms, and JC virus index values can aid in making informed treatment decisions.
Article Synopsis
- Rituximab has shown significant benefits for treating B-cell lymphoma and various autoimmune diseases, but its effects are limited in central nervous system (CNS) disorders due to the blood-brain barrier.
- Multiple sclerosis (MS), particularly its progressive phase, is a key CNS autoimmune disorder that resists existing treatments, highlighting the potential of intrathecal (IT) therapies to deliver drugs directly to the affected area.
- The review discusses findings from animal studies and human cases using intrathecal rituximab for CNS lymphomas and emphasizes the need for clinical trials on its use in multiple sclerosis, providing foundational data for future CNS autoimmune research.
We report 2 patients with ischemic stroke related to an initial severe focal narrowed middle cerebral artery caused by a dissection mechanism, a presentation that has received little attention to date. Diagnostic modalities and follow-up using transcranial color-coded sonography are reported and discussed. Results with transcranial color-coded sonography were correlated with computed tomographic angiography, showing the great value of this radiation-free arterial monitoring process in this setting, especially in young adults.
View Article and Find Full Text PDFBackground: Chorea-acanthocytosis (ChAc) is a neuroacanthocytosis syndrome presenting with severe movement disorders poorly responsive to drug therapy. Case reports suggest that bilateral deep brain stimulation (DBS) of the ventro-postero-lateral internal globus pallidus (GPi) may benefit these patients. To explore this issue, the present multicentre (n=12) retrospective study collected the short and long term outcome of 15 patients who underwent DBS.
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