Publications by authors named "Marie Magdeleine Coude"
Int J Lab Hematol
October 2022
Article Synopsis
- The ASXL1 gene is often mutated in blood cancers, particularly the c.1934dupG mutation, which is linked to worse patient outcomes, highlighting the need for better detection methods.
- Researchers developed a new assay called "PCR-Fluo-ASXL1-FA" that rapidly and cost-effectively detects the c.1934dupG mutation and other nearby insertions/deletions, in contrast to less sensitive methods like direct sequencing.
- Their study showed that this new approach is highly effective and should be used alongside next-generation sequencing (NGS) for comprehensive detection of ASXL1 mutations in myeloid malignancies.
J Clin Oncol
January 2017
Article Synopsis
- This study evaluated the impact of NPM1-mutated minimal residual disease (MRD) on young adult patients with acute myeloid leukemia (AML) to see if it could help predict the benefits of stem cell transplantation.
- Among 152 patients analyzed after induction therapy, those with less than a 4-log reduction in MRD had a significantly higher chance of relapse and shorter overall survival.
- The findings suggest that early NPM1m MRD evaluation is a crucial prognostic tool and can guide decisions regarding the use of allogeneic stem cell transplantation in patients with unfavorable AML.
