[Cost-effective change in treatment after split skin grafting to lower leg defects].

We present a clinical comparison of short stretch bandage versus a two-layer compression bandage and early mobilization after split skin grafting to lower leg defects. A total of 38 patients were included. The first group were immobilized for four days and given a short stretch support bandage.

Persistent pain after surgery for cutaneous melanoma.

Objectives: Chronic pain is a well-known complication after surgery, but the prevalence of persistent pain after melanoma surgery is unknown. This study examined the prevalence and predictors of persistent pain after melanoma surgery.

Methods: Between September 2005 and June 2009, 448 patients underwent surgery for cutaneous melanoma at the Department of Plastic Surgery, Aalborg Hospital.

[Unusual long-term survival following non-radical treatment of oral mucosal melanoma].

Malignant mucosal melanomas are rare and aggressive. The five-year survival rate for malignant oral melanomas is 15%. A case of a 65-year old male with progressive melanosis in the oral mucus and development of four malignant melanomas during a 15-year follow-up period is presented.

[Adult onset xanthogranuloma in a 73-year-old woman].

Adult onset xanthogranuloma (AOX) is a rare benign xanthogranulomatous disease with unknown aetiology and incidence. AOX presents as yellow-brownish skin tumours of different sizes, mostly as solitary lesions, but also as multiple lesions with predilection areas on the face and collum. We here present the case of a 73-year-old woman, who was treated for third and fourth facial AOX recurrences by surgical excisions at the Department of Plastic Surgery, Aalborg Hospital.

Intraneuronal signaling pathways of metallothionein.

Metallothionein (MT) belongs to a family of metal-binding cysteine-rich proteins comprising several structurally related proteins implicated in tissue protection and regeneration after injuries and functioning as antiapoptotic antioxidants in neurological disorders. This has been demonstrated in animals receiving MT treatment and in mice with endogenous MT overexpression or null mutation during various experimental models of neuropathology, and also in patients with Alzheimer's disease and amyotrophic lateral sclerosis. Exogenously applied MT increases neurite outgrowth and neuronal survival in rat cerebellar, hippocampal, dopaminergic, and cortical neurons in vitro.