Publications by authors named "Marie Lavaut"
Article Synopsis
- Phage display is a method to find binders for various antigens, which can be tested both on purified proteins and whole cells, but its efficiency can be inconsistent due to challenges in selection steps.* -
- A new technique called masked selection improves the process by blocking unwanted binding sites, allowing researchers to focus on relevant targets, demonstrated by successfully isolating antibodies against certain proteins and cancer markers.* -
- This approach was validated by identifying specific breast cancer markers and can be utilized for diverse types of antibody fragments, making it beneficial for swiftly discovering important cell surface markers.*
The immunocytochemical detection of Tie-2/Tek, CD105, and CD31 was assessed in a large series (n = 905) of breast carcinomas on frozen sections. Results were correlated with patients' long-term outcome (median, 11.7 years) to define the respective prognostic significance of these markers.
View Article and Find Full Text PDFObjectives: The aim of this study was to investigate the prognostic value of vascular endothelial growth factor (VEGF) receptors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1) in breast carcinoma.
Methods: VEGF receptor expression was investigated using immunohistochemical assays with monoclonal antibodies on frozen sections in a series of 918 patients and was correlated with prognostic parameters and with long-term follow-up (median, 11.3 years).